Ferritin protein nanocages use ion channels, catalytic sites, and nucleation channels to manage iron/oxygen chemistry.
Ferritin protein nanocages use ion channels, catalytic sites, and nucleation channels to manage iron/oxygen chemistry.
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DOI：
10.1016/j.cbpa.2011.01.004
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发表时间：
2011-04
影响因子：
7.8
通讯作者：
Theil, Elizabeth C.
中科院分区：
文献类型：
--
作者：
Theil, Elizabeth C.
铁蛋白超家族由古老的纳米笼蛋白组成，具有内腔，占总体积的60%，可逆地合成水合氧化铁的固体矿物质;矿物质是用于细胞营养的铁浓缩物以及由于矿化过程中亚铁和氧的消耗而产生的抗氧化剂。笼有多个铁入口/出口通道，氧化还原酶位点，并在真核生物中，Fe（III）O成核通道与集群出口，扩展蛋白质活性，包括促进矿物生长。铁蛋白笼的差异包括大小、氨基酸序列、活性位点的位置、氧化剂底物和铁矿物的结晶度。遗传调节依赖于铁和氧信号，在动物中包括直接亚铁信号到RNA以释放和到泛素连接酶以降解蛋白质阻遏物。铁蛋白生物合成与DNA、mRNA和蛋白质产物形成反馈回路，其中遗传信号也是蛋白质底物。铁蛋白纳米笼是正常铁稳态所需的，目前正用于纳米药物、新型纳米材料和纳米催化剂的递送，可能有助于从厌氧生活过渡到有氧生活期间的生存和成功。
The ferritin superfamily is composed of ancient, nanocage proteins with an internal cavity, 60% of total volume, that reversibly synthesize solid minerals of hydrated ferric oxide; the minerals are iron concentrates for cell nutrition as well as antioxidants due to ferrous and oxygen consumption during mineralization. The cages have multiple iron entry/exit channels, oxidoreductase enzyme sites, and, in eukaryotes, Fe(III)O nucleation channels with clustered exits that extend protein activity to include facilitated mineral growth. Ferritin protein cage differences include size, amino acid sequence, and location of the active sites, oxidant substrate and crystallinity of the iron mineral. Genetic regulation depends on iron and oxygen signals, which in animals includes direct ferrous signaling to RNA to release and to ubiquitin-ligases to degrade the protein repressors. Ferritin biosynthesis forms, with DNA, mRNA and the protein product, a feedback loop where the genetic signals are also protein substrates. The ferritin protein nanocages, which are required for normal iron homeostasis and are finding current use in delivery of nanodrugs, novel nanomaterials, and nanocatalysts, are likely contributors to survival and success during the transition from anaerobic to aerobic life.
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影响因子：
5.6
作者：
MANN, S;WILLIAMS, JM;HARRISON, PM
通讯作者：
HARRISON, PM
影响因子：
4.8
作者：
Ferreira, C;Bucchini, D;Beaumont, C
通讯作者：
Beaumont, C
影响因子：
15
作者：
Abe, Satoshi;Hirata, Kunio;Watanabe, Yoshihito
通讯作者：
Watanabe, Yoshihito
影响因子：
2.7
作者：
Deng, Q. Y.;Yang, B.;Wang, X. N.
通讯作者：
Wang, X. N.
DOI：
10.1107/s0907444997003983
发表时间：
1997-09-01
影响因子：
2.2
作者：
Ha, Y;Theil, EC;Allewell, NM
通讯作者：
Allewell, NM