Usefulness of cardiorespiratory fitness to predict coronary heart disease risk independent of physical activity.
Usefulness of cardiorespiratory fitness to predict coronary heart disease risk independent of physical activity.
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心肺健康在预测冠心病风险方面的作用与体力活动无关。
DOI：
10.1016/j.amjcard.2010.03.017
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Williams,PaulT
中科院分区：
文献类型：
--
作者：
Williams,PaulT
心肺适合度通常被解释为体力活动的替代测量，而不是本身就是一个独立的冠心病(CHD)风险因素。然而，健康也被认为是高度可遗传的，即使在缺乏体力活动的情况下，为跑步机耐力而选择性饲养的大鼠也具有较低的冠心病风险表型。因此，作为国家跑步者健康研究的一部分，我对29,721名男性进行了7.7年的前瞻性跟踪，评估了心肺健康状况是否独立于体力活动预测冠心病。具体地说，将随访期间的冠心病死亡和参与者报告的事件-医生诊断的心肌梗死、血运重建手术(冠状动脉搭桥术和经皮冠状动脉介入治疗)和心绞痛与基线心肺功能(10公里赛跑成绩，米/秒)进行比较。提供随访问卷的80%的男性患者的非致命性终点包括121例非致命性心肌梗死、317例血管重建术和81例心绞痛。国家死亡指数确定了44例冠心病死亡病例。基线健康每增加一米/秒，男性患非致命性心肌梗死的风险降低54%(p<；0.0001)，合并冠心病和非致命性心肌梗死的风险降低44%(p=0.0003)，心绞痛的风险降低53%(p=0.001)，血管重建术的风险降低32%(p=0.002)。体力活动(公里/日跑)的调整对非致命性心肌梗死(%至63%)、冠心病死亡和非致命性心肌梗死(34%至33%)、心绞痛(53%至47%)或血管重建(32%至26%)的每米/秒风险降低几乎没有影响。综上所述，这些结果表明心肺健康是冠心病的危险因素，在很大程度上独立于体力活动，这值得进行临床筛查。
Cardiorespiratory fitness has often been interpreted as a surrogate measurement of physical activity rather than an independent coronary heart disease (CHD) risk factor per se. Fitness is also known to be highly heritable, however, and rats bred selectively for treadmill endurance have low CHD risk phenotypes even in the absence of physical activity. Therefore, I assessed whether cardiorespiratory fitness predicted CHD independent of physical activity in 29,721 men followed prospectively for 7.7 years as part of the National Runners' Health Study. Specifically, CHD deaths and incident participant-reported physician-diagnosed myocardial infarction, revascularization procedures (coronary artery bypass grafting and percutaneous coronary intervention), and angina pectoris during follow-up were compared to baseline cardiorespiratory fitness (10-km footrace performance, meters/second). Nonfatal end points for the 80% of these men who provided follow-up questionnaires included 121 nonfatal myocardial infarctions, 317 revascularization procedures, and 81 angina pectora. The National Death Index identified 44 CHD deaths. Per meter/second increment in baseline fitness, men's risks decreased 54% for nonfatal myocardial infarction (p <0.0001), 44% for combined CHD deaths and nonfatal myocardial infarction (p = 0.0003), 53% for angina pectoris (p = 0.001), and 32% for revascularizations (p = 0.002). Adjustment for physical activity (kilometer/day run) had little effect on the per meter/second risk decreases for nonfatal myocardial infarction (from 64% to 63%), combined CHD deaths and nonfatal myocardial infarction (from 34% to 33%), angina pectoris (from 53% to 47%) or revascularizations (from 32% to 26%). In conclusion, the results suggest that cardiorespiratory fitness is a CHD risk factor, largely independent of physical activity, which warrants clinical screening.
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DOI：
10.1097/00005768-200105000-00012
发表时间：
2001-05-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Williams, PT
通讯作者：
Williams, PT
影响因子：
--
作者：
Williams,PT
通讯作者：
Williams,PT
影响因子：
3.3
作者：
Bouchard, C;An, P;Rao, DC
通讯作者：
Rao, DC
影响因子：
5
作者：
COLDITZ, GA;MARTIN, P;SPEIZER, FE
通讯作者：
SPEIZER, FE
运动中的气体交换
影响因子：
5.8
作者：
P. Cerretelli;P. E. D. Prampero
通讯作者：
P. E. D. Prampero