Non-Invasive Diagnostic System Based on Light for Detecting Early-Stage Oral Cancer and High-Risk Precancerous Lesions-Potential for Dentistry.
Non-Invasive Diagnostic System Based on Light for Detecting Early-Stage Oral Cancer and High-Risk Precancerous Lesions-Potential for Dentistry.
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基于光的非侵入性诊断系统，用于检测早期口腔癌和高风险癌前病变 - 牙科潜力。
DOI：
10.3390/cancers12113185
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发表时间：
2020-10-29
期刊：
影响因子：
5.2
通讯作者：
Satomura K
中科院分区：
文献类型：
--
作者：
Tatehara S;Satomura K
口腔癌和口腔潜在恶性疾病的早期检测可以促进最小的干预和治疗后预后和生活质量的后续改善。最近，几种非侵入性的基于荧光的检测系统已经提高了口腔癌和口腔潜在恶性疾病的检测和诊断的准确性。本文总结了目前的知识，荧光为基础的诊断方法，并讨论其优点和缺点，从临床的角度来看。口腔健康促进和检查有助于早期发现口腔癌和口腔潜在恶性疾病，从而适应微创治疗，并随后改善治疗后的预后/维持生活质量。然而，早期口腔癌和口腔上皮异常增生的准确检测对于常规口腔检查来说特别困难，因为这些病变有时类似于良性病变或健康的口腔粘膜组织。虽然口腔活检被认为是准确诊断的金标准，但它对患者来说是侵入性的。出于这个原因，大多数临床医生都期待着非侵入性诊断技术的发展，以检测和区分癌性和良性病变。迄今为止，几种非侵入性的基于荧光的检测系统已经提高了口腔粘膜病变的检测和诊断的准确性。基于自体荧光的系统可以通过用蓝紫光照射来检测作为自体荧光损失的病变。使用5-氨基乙酰丙酸（ALA-PDD）的光动力学诊断显示了非常早期的口腔癌和口腔上皮异型增生的存在，作为红色荧光区域。本文从临床角度介绍和讨论了目前常用的荧光诊断方法。
The early detection of oral cancer and oral potentially malignant disorders can facilitate minimum intervention and subsequent improvements in prognosis and quality of life after treatment. Recently, several non-invasive adjunctive fluorescence-based detection systems have improved the accuracy of detection and diagnosis of oral cancer and oral potentially malignant disorders. This article summarizes current knowledge about fluorescence-based diagnostic methods and discusses their benefits and drawbacks from a clinical viewpoint. Oral health promotion and examinations have contributed to the early detection of oral cancer and oral potentially malignant disorders, leading to the adaptation of minimally invasive therapies and subsequent improvements in the prognosis/maintenance of the quality of life after treatments. However, the accurate detection of early-stage oral cancer and oral epithelial dysplasia is particularly difficult for conventional oral examinations because these lesions sometimes resemble benign lesions or healthy oral mucosa tissues. Although oral biopsy has been considered the gold standard for accurate diagnosis, it is deemed invasive for patients. For this reason, most clinicians are looking forward to the development of non-invasive diagnostic technologies to detect and distinguish between cancerous and benign lesions. To date, several non-invasive adjunctive fluorescence-based detection systems have improved the accuracy of the detection and diagnosis of oral mucosal lesions. Autofluorescence-based systems can detect lesions as a loss of autofluorescence through irradiation with blue-violet lights. Photodynamic diagnosis using 5-aminolevulinic acid (ALA-PDD) shows the presence of very early oral cancers and oral epithelial dysplasia as a red fluorescent area. In this article, currently used fluorescence-based diagnostic methods are introduced and discussed from a clinical point of view.
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影响因子：
3.3
作者：
Awan, K. H.;Morgan, P. R.;Warnakulasuriya, S.
通讯作者：
Warnakulasuriya, S.
DOI：
10.14219/jada.archive.2012.0096
发表时间：
2012-12-01
影响因子：
3.9
作者：
Epstein, Joel B.;Guneri, Pelin;Abt, Elliot
通讯作者：
Abt, Elliot
影响因子：
4.8
作者：
Huang, Tze-Ta;Huang, Jehn-Shyun;Chung, Pau-Choo
通讯作者：
Chung, Pau-Choo
DOI：
10.1016/1011-1344(90)85083-9
发表时间：
1990-06-01
影响因子：
5.4
作者：
KENNEDY, JC;POTTIER, RH;PROSS, DC
通讯作者：
PROSS, DC
影响因子：
--
作者：
Chaudhry, Astha;Manjunath, Muniraju;Krishna, Annaji Gopal
通讯作者：
Krishna, Annaji Gopal