Extracellular Vesicles in Pulmonary Fibrosis Models and Biological Fluids of Interstitial Lung Disease Patients: A Scoping Review.
Extracellular Vesicles in Pulmonary Fibrosis Models and Biological Fluids of Interstitial Lung Disease Patients: A Scoping Review.
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肺纤维化模型中的细胞外囊泡和间质性肺病患者的生物体液：范围综述
DOI：
10.3390/life11121401
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发表时间：
2021-12-15
期刊：
影响因子：
--
通讯作者：
Vidal S
中科院分区：
文献类型：
--
作者：
d'Alessandro M;Bergantini L;Bargagli E;Vidal S
简介：间质性肺疾病（ILD）是一组异质性的弥漫性肺实质疾病，其特征在于病原体参与。因此，阐明这些疾病的病因和发病机制以及鉴定诊断和预后生物标志物比以往任何时候都更加引人注目。值得注意的是，越来越多的证据表明细胞外囊泡（EV）参与了包括肺癌、慢性阻塞性肺病和肺纤维化在内的肺部疾病的发病机制。据推测，EV作为细胞间通讯的介导者发挥着关键作用，并突出了EV作为肺部疾病（如IPF）发展中的合作者的作用。研究方法：本研究旨在对文献进行系统性探索性检索（通过范围审查方法），以确定和系统化EV在肺纤维化模型和ILD患者生物体液（包括血浆、支气管肺泡灌洗液（BAL）和痰液）中的致病作用的主要结果。结论：成纤维细胞向间充质细胞分化、胶原和细胞外基质沉积是IPF发生和进展的关键机制。EV偶联的miRNA在肺纤维化模型以及生物流体中显示的细胞间通讯方面是生物过程的重要调节剂。EV作为诊断和治疗诊断标志物的有用性值得进一步研究。由于IPF患者迫切需要新的治疗策略，EV将有效的基于EV的治疗转化为临床实践的潜力日益受到关注。
Introduction: Interstitial lung diseases (ILDs) are a heterogeneous group of diffuse parenchymal lung disorders characterized by the pathogenetic involvement of interstitium. Therefore, an elucidation of the etiology and pathogenesis as well as the identification of diagnostic and prognostic biomarkers of such diseases is more compelling than ever. It is of note that there is increasing evidence of the involvement of extracellular vesicles (EVs) in the pathogenesis of lung diseases including lung cancer, chronic obstructive pulmonary disease and pulmonary fibrosis. It has been speculated that EVs play a pivotal role as mediators of intercellular communication, as well as the highlighting of the role of EVs as co-operators in the development of lung diseases such as IPF. Methods: The present study aimed to carry out a systematic exploratory search of the literature (through the scoping review approach) to identify and systematize the main results of the pathogenetic role of EVs in pulmonary fibrosis models and biological fluids from ILD patients, including plasma, bronchoalveolar lavage (BAL) and sputum. Conclusion: Fibroblast-to-mesenchymal differentiation, collagen and extracellular matrix deposition are key mechanisms in the development and progression of IPF. EV-coupled miRNA are important modulators of biological processes in terms of intercellular communication as shown in pulmonary fibrosis models as well as biofluids. The helpfulness of EVs as diagnostic and theranostic markers is worth further investigation. The evolving potential of EVs to translate effective EV-based therapies into clinical practice is of growing interest, due to the urgent need for novel therapeutic strategies for IPF patients.
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影响因子：
4.7
作者：
D'alessandro, Miriana;Bergantini, Laura;Bargagli, Elena
通讯作者：
Bargagli, Elena
影响因子：
9.6
作者：
Hou, Peter C.;Filbin, Michael R.;Shapiro, Nathan I.
通讯作者：
Shapiro, Nathan I.
影响因子：
--
作者：
Komura, Kazubiro;Yanaba, Koichi;Sato, Shinichi
通讯作者：
Sato, Shinichi
影响因子：
10
作者：
Guiot J;Cambier M;Boeckx A;Henket M;Nivelles O;Gester F;Louis E;Malaise M;Dequiedt F;Louis R;Struman I;Njock MS
通讯作者：
Njock MS
影响因子：
6
作者：
d'Alessandro M;Soccio P;Bergantini L;Cameli P;Scioscia G;Foschino Barbaro MP;Lacedonia D;Bargagli E
通讯作者：
Bargagli E