The Impact of Increased Bladder Blood Flow on Storage Symptoms after Holmium Laser Enucleation of the Prostate.
The Impact of Increased Bladder Blood Flow on Storage Symptoms after Holmium Laser Enucleation of the Prostate.
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前列腺钬激光去核术后膀胱血流增加对储尿症状的影响
DOI：
10.1371/journal.pone.0129111
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Horie S
中科院分区：
文献类型：
--
作者：
Saito K;Hisasue S;Ide H;Aoki H;Muto S;Yamaguchi R;Tsujimura A;Horie S
为了研究钬激光前列腺摘除术（HoLEP）如何改善储尿症状，我们评估了良性前列腺增生症（BPH）患者激光手术前后膀胱粘膜的血流量。74例连续BPH患者（中位年龄69岁，范围：53-88岁）在我们的机构接受了HoLEP，并被纳入本研究。我们前瞻性评估了术前和术后的国际前列腺症状评分（IPSS）、IPSS-QOL评分、膀胱过度活动症评分（OABSS）、尿流率和膀胱血流量。使用OMEGA FLOW（OMEGA WAVE，Tokyo，Japan）激光多普勒流量计测量膀胱粘膜中的血流。摘除腺瘤的中位体积为45.0 g（范围：25.0 - 83.2）。中位IPSS从20（范围：6-35）显著改善至3（0-22）（p<0.001; Wilcoxon符号秩检验），储存症状评分也是如此，从13（2-20）降至3（1-8）（p<0.001）。三角区的中位膀胱血流量从9.57±0.83 ml/sec增加至17.60±1.08 ml/sec。对改善的储尿症状评分的多元回归分析排除了除膀胱灌注增加外的所有解释变量。数据表明，HoLEP改善了膀胱粘膜的血流量，这独立地导致储尿症状的改善。
In order to investigate how holmium laser enucleation of the prostate (HoLEP) improves urinary storage symptoms, we assessed blood flow in the urinary bladder mucosa of patients with benign prostatic hyperplasia (BPH) before and after laser surgery. Seventy-four consecutive patients with BPH (median age 69 years, range; 53–88) underwent HoLEP at our institution and are included in this study. We prospectively assessed the International Prostate Symptom Score (IPSS), IPSS-QOL Score, the Overactive Bladder Symptom Score (OABSS), uroflowmetry, and blood flow in the urinary bladder, before and after surgery. Blood flow in the bladder mucosa was measured using the OMEGA FLOW (OMEGAWAVE, Tokyo, Japan) laser Doppler flowmeter. The median volume of the enucleated adenomas was 45.0 g (range: 25.0 to 83.2). The median IPSS improved significantly from 20 (range: 6–35) to 3 (0–22) (p<0.001; Wilcoxon signed-rank test), as did the storage symptoms score, which decreased from 13 (2–20) to 3 (1–8) (p<0.001). Median bladder blood flow increased at the trigone from 9.57±0.83 ml/sec to 17.60±1.08 ml/sec. Multiple regression analysis for the improved storage symptom score eliminated all explanatory variables except increased bladder perfusion. The data suggest that HoLEP improves blood flow in the bladder mucosa, which independently leads to the improvement of storage symptoms.
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影响因子：
6.6
作者：
ABRAMS, PH;FARRAR, DJ;FENELEY, RCL
通讯作者：
FENELEY, RCL
影响因子：
2.1
作者：
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作者：
Pinggera, Germar-Michael;Mitterberger, Michael;Strasser, Hannes
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2.1
作者：
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通讯作者：
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影响因子：
4.5
作者：
Mitterberger, Michael;Pallwein, Leo;Pinggera, Germar-Michael
通讯作者：
Pinggera, Germar-Michael