Longitudinal diffusion tensor imaging in a rat brain glioma model.
Longitudinal diffusion tensor imaging in a rat brain glioma model.
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DOI：
10.1002/nbm.1256
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发表时间：
2008-10
影响因子：
2.9
通讯作者：
Trouard, Theodore P.
中科院分区：
文献类型：
--
作者：
Lope-Piedrafita, Silvia;Garcia-Martin, Maria L.;Galons, Jean-Philippe;Gillies, Robert J.;Trouard, Theodore P.
为了研究脑肿瘤内部和周围的水运动特性作为肿瘤生长的函数，在大鼠脑胶质瘤（C6）模型中进行了纵向扩散张量成像（DTI）。随着肿瘤体积的增大，在肿瘤内部和周围都观察到水扩散的显著各向异性。肿瘤周围的组织水表现出高的平面各向异性，而不是线性各向异性通常在白色物质中看到的，表明细胞在垂直于肿瘤边界的方向上经历应力。当肿瘤足够大时，由于肿瘤边界内癌细胞的较长范围组织，在肿瘤内也观察到显著的各向异性。这些发现对研究肿瘤生长和治疗反应的扩散加权MRI实验具有重要意义。
In order to investigate the properties of water motion within and around brain tumors as a function of tumor growth, longitudinal diffusion tensor imaging (DTI) was carried out in a rat brain glioma (C6) model. As tumors grow in size, significant anisotropy of water diffusion was seen both within and around the tumor. The tissue water surrounding the tumor exhibited high planar anisotropy, as opposed to linear anisotropy normally seen in white matter, indicating that cells were experiencing stress in a direction normal to the tumor border. When tumors were sufficiently large, significant anisotropy was also seen within the tumor due to longer range organization of cancer cells within the tumor borders. These findings have important implications for diffusion-weighted MRI experiments studying tumor growth and response to therapy.
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影响因子：
3.3
作者：
Bennett, Kevin M.;Hyde, James S.;Schmainda, Kathleen M.
通讯作者：
Schmainda, Kathleen M.
影响因子：
4.8
作者：
Plaks, V;Koudinova, N;Salomon, Y
通讯作者：
Salomon, Y
影响因子：
3.3
作者：
Sarlls, JE;Newbould, RD;Trouard, TP
通讯作者：
Trouard, TP
影响因子：
19.7
作者：
Lu, S;Ahn, D;Grossman, RI
通讯作者：
Grossman, RI
影响因子：
3.3
作者：
Bennett, KM;Hyde, JS;Schmainda, KM
通讯作者：
Schmainda, KM