Eaten to death.

Eaten to death.
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被吃掉。

DOI:
10.1111/febs.13114
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发表时间:
2014-12
期刊:
The FEBS journal
影响因子:
--
通讯作者:
Baehrecke EH
Baehrecke EH
中科院分区:
其他
文献类型:
--
作者:
Nelson C;Baehrecke EH

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大自噬(Macro-autophagy)(以下称为自噬)将细胞质物质递送至溶酶体以进行降解,并且已经涉及许多细胞过程,包括应激、感染、存活和死亡。虽然自噬在应激、感染和存活中的调节和作用是显而易见的,但自噬在细胞死亡期间的调节和作用仍然相对不清楚。在这篇综述中,我们强调了自噬在生理细胞死亡过程中所起的作用,并讨论了更好地理解涉及自噬的细胞破坏的影响。
Macro-autophagy (hereafter referred to as autophagy) delivers cytoplasmic material to the lysosome for degradation, and has been implicated in many cellular processes, including stress, infection, survival, and death. While the regulation and role that autophagy plays in stress, infection, and survival is apparent, the regulation of and role that autophagy has during cell death remains relatively unclear. In this review, we highlight what is known about the role that autophagy can play during physiological cell death, and discuss the implications of better understanding cellular destruction that involves autophagy.
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