Therapeutic alternatives in the management of osteoradionecrosis of the jaws. Systematic review.
Therapeutic alternatives in the management of osteoradionecrosis of the jaws. Systematic review.
复制标题
DOI：
10.4317/medoral.24132
复制
发表时间：
2021-03-01
期刊：
影响因子：
--
通讯作者：
Pérez Sayáns M
中科院分区：
文献类型：
--
作者：
Camolesi GC;Ortega KL;Medina JB;Campos L;Lorenzo Pouso AI;Gándara Vila P;Pérez Sayáns M
系统回顾文献，比较放射骨坏死(ORN)的治疗方法：手术治疗、药物治疗和综合治疗。回顾是根据Prisma方案组织的，涉及以下PICO问题：颌骨ORN患者(P=患者)；报告的所有干预(I=干预)；所有治疗之间(C=比较)；损伤的愈合(O=结果)。手术治疗是最常见的选择(46.3%)，其次是药物治疗(25.9%)或联合治疗(26.9%)。单纯手术治疗似乎是最有效的治疗方法，51.2%的皮损愈合，或5.7%愈合(CI95%1.9-16.9，p=0.002)。仅1例(0.9%)对应于低强度激光治疗。早期保守手术结合药物治疗可改善ORN的预后。关键词：放射性骨坏死、放疗性骨坏死、高压氧、己酮可可碱、特瑞帕雷、低强度激光治疗。
to systematically review the literature, comparing the healing of osteoradionecrosis (ORN) among the therapeutic alternatives: surgical, pharmacological and combined. The review was organized according to the PRISMA protocol with regards to the following PICO question: patients with ORN of the jaws (P=Patient); all interventions reported (I = intervention); between all therapies (C=Comparison); healing of lesions (O=outcome). Surgical treatment was the most common choice (46.3%) followed by pharmacological treatment, exclusively (25.9%) or combined (26.9%). Treatment exclusively by surgical intervention seems to be most effective option, with 51.2% of the lesions healed, OR for healing of 5.7 (CI95% 1.9-16.9, p=0.002). Only 1 case (0.9%) corresponded to low level laser therapy. It seems clear that early intervention with conservative surgical combined with pharmacological methods improves the prognosis of ORN. Key words:Osteoradionecrosis, radiotherapy bone necrosis, hyperbaric oxygen, pentoxifylline, teriparatide, low level laser therapy.
登录
查看更多内容
影响因子：
15.8
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
DOI：
10.3988/jcn.2018.14.1.35
发表时间：
2018-01
期刊：
Journal of clinical neurology (Seoul, Korea)
影响因子：
--
作者：
Kim BJ;Kang HG;Lee SW;Jung J;Lee MH;Kang DW;Kim JS;Kwon SU
通讯作者：
Kwon SU
DOI：
10.1002/hed.25681
发表时间：
2019-07-01
影响因子：
2.9
作者：
Danielsson, Daniel;Munck-Wikland, Eva;Halle, Martin
通讯作者：
Halle, Martin
影响因子：
0.9
作者：
Gallesio, Giorgia;Del Fabbro, Massimo;Mozzati, Marco
通讯作者：
Mozzati, Marco
影响因子：
1.3
作者：
Murthy, Vedang;Gupta, Tejpal;Agarwal, Jaiprakash
通讯作者：
Agarwal, Jaiprakash