Maiden outbreak of chikungunya in Dongguan city, Guangdong province, China: epidemiological characteristics.
Maiden outbreak of chikungunya in Dongguan city, Guangdong province, China: epidemiological characteristics.
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DOI：
10.1371/journal.pone.0042830
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Pinghua C
中科院分区：
文献类型：
--
作者：
Qiaoli Z;Jianfeng H;De W;Zijun W;Xinguang Z;Haojie Z;Fan D;Zhiquan L;Shiwen W;Zhenyu H;Yonghui Z;Changwen K;Dakang Y;Wenjia L;Deqiong L;Pinghua C
本研究旨在了解我国首次暴发的鸡立克次体热疫情的流行病学特征，并对预防措施的效果进行评价。2010年9月1日至10月29日，广东省东莞市万江区新村社区发生我国首例CHIK热暴发疫情，共报告病例253例，实验室确诊129例，发病率为1%。9月18日之前，新村社区的鸡立克次体热病例数相对较低; 9月19日起，病例数急剧增加，10月4日达到暴发高峰。病例分布于新村社区9个小村组，村级发病率为0-12%。家庭攻击率在20%到100%之间。男女发病率无显著性差异。不同年龄组的发作率存在显著差异（卡方= 18.35，p = 0.005）; 60岁或以上患者最高，10岁以下患者最低。 主要临床表现为发热（100%）、关节痛（79%）和皮疹（54%）。对5例最早确诊病例的E1基因进行系统发育分析显示，从其血清中分离的CHIKV毒株与2009年在泰国分离的同基因毒株高度同源（高达99%）。采取灭杀成蚊、清理伊蚊孳生地等防治措施后，布雷托指数和诱蚊产卵器指数迅速下降，疫情于10月29日结束。这次疫情的传染源是输入性的。病例在暴发期间具有明显的时间、空间和人群聚集性。以降低伊蚊密度为主的综合防治措施对控制疫情是有效的。
This study was conducted to identify epidemiological characteristics of the first documented CHIK fever outbreak in China and evaluate the effect of the preventive measures taken. From September 1 to October 29, 2010, China's first documented outbreak of CHIK fever occurred in the Xincun community of Wanjiang District of Dongguan city, Guangdong province; 253 case-patients were recorded, of which 129 were laboratory confirmed, with an attack rate of 1%. Before September 18th the number of CHIK fever cases remained relatively low in the Xincun community; from September 19th onwards, the number of cases increased drastically, with an outbreak peak on October 4th. Cases were distributed across nine small village groups in the Xincun community, with an attack rate of 0–12% at the village level. The household attack rates ranged between 20% and 100%. No significant difference was found in the attack rate between males and females. There was a significant difference in the attack rate in different age groups (chi-square = 18.35, p = 0.005); highest in patients aged 60 years or older and the lowest in patients aged under 10. The major clinical characteristics of patients are fever (100%), joint pain (79%) and rash (54%). Phylogenetic analysis of the E1 gene on the five earliest confirmed cases showed that the strains of CHIKV isolated from their sera were highly homologous (up to 99%) with isogeneic strains isolated in Thailand in 2009. After control measures were taken, including killing adult mosquitoes and cleaning breeding habitats of Aedes mosquitoes, the Breteau index and Mosq-ovitrap index decreased rapidly, and the outbreak ended on October 29. The infection source of the outbreak was imported. Cases showed obvious temporal, spatial, and population aggregation during the outbreak. Comprehensive control measures based on reducing the density of Aedes mosquitoes were effective in controlling the epidemic.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
10.1016/j.trstmh.2004.03.013
发表时间：
2005-02-01
影响因子：
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作者：
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通讯作者：
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