Stress and addiction: contribution of the corticotropin releasing factor (CRF) system in neuroplasticity.
Stress and addiction: contribution of the corticotropin releasing factor (CRF) system in neuroplasticity.
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DOI：
10.3389/fnmol.2012.00091
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发表时间：
2012
影响因子：
4.8
通讯作者：
Bartlett SE
中科院分区：
文献类型：
--
作者：
Haass-Koffler CL;Bartlett SE
促肾上腺皮质激素释放因子（CRF）已被证明可诱导与适应应激有关的各种行为变化。CRF系统在任何时候的失调都可能导致各种精神疾病，包括物质使用障碍（SUD）。CRF与应激诱导的药物强化有关。大量文献已确定CRF在导致SUD复发的易感性增加的分子机制中发挥重要作用。CRF系统在SUD中的作用各不相同。它增强了滥用药物的急性效应，也是在戒断期诱发的药物诱导的神经可塑性增强的原因。我们在这篇综述中提出的大脑区域和电路CRF的表达，并可能参与应激诱导的药物滥用。最后，我们试图评估调节CRF系统的作用，作为一种可能的治疗策略，用于治疗由滥用物质的急性正强化以及由戒断产生的负强化引起的情绪行为失调。
Corticotropin releasing factor (CRF) has been shown to induce various behavioral changes related to adaptation to stress. Dysregulation of the CRF system at any point can lead to a variety of psychiatric disorders, including substance use disorders (SUDs). CRF has been associated with stress-induced drug reinforcement. Extensive literature has identified CRF to play an important role in the molecular mechanisms that lead to an increase in susceptibility that precipitates relapse to SUDs. The CRF system has a heterogeneous role in SUDs. It enhances the acute effects of drugs of abuse and is also responsible for the potentiation of drug-induced neuroplasticity evoked during the withdrawal period. We present in this review the brain regions and circuitries where CRF is expressed and may participate in stress-induced drug abuse. Finally, we attempt to evaluate the role of modulating the CRF system as a possible therapeutic strategy for treating the dysregulation of emotional behaviors that result from the acute positive reinforcement of substances of abuse as well as the negative reinforcement produced by withdrawal.
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影响因子：
16.2
作者：
CHANG, CP;PEARSE, RV;ROSENFELD, MG
通讯作者：
ROSENFELD, MG
影响因子：
2.6
作者：
Bale, TL;Lee, KF;Vale, WW
通讯作者：
Vale, WW
DOI：
10.1073/pnas.0802302105
发表时间：
2008-06-17
影响因子：
11.1
作者：
Bajo, Michal;Cruz, Maureen T.;Roberto, Marisa
通讯作者：
Roberto, Marisa
影响因子：
3.4
作者：
BALDWIN, HA;RASSNICK, S;BRITTON, KT
通讯作者：
BRITTON, KT
影响因子：
2.9
作者：
CADOR, M;COLE, BJ;LEMOAL, M
通讯作者：
LEMOAL, M