Altered excitation-inhibition balance in the brain of patients with diabetic neuropathy.
Altered excitation-inhibition balance in the brain of patients with diabetic neuropathy.
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DOI：
10.1016/j.acra.2012.02.004
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发表时间：
2012-05
影响因子：
4.8
通讯作者：
Feldman, Eva L.
中科院分区：
文献类型：
--
作者：
Petrou, Myria;Pop-Busui, Rodica;Foerster, Bradley R.;Edden, Richard A.;Callaghan, Brian C.;Harte, Steve E.;Harris, Richard E.;Clauw, Daniel J.;Feldman, Eva L.
在糖尿病神经病变（DN）、阳性感觉症状患者和年龄匹配的健康对照（HC）受试者的大脑疼痛处理区，利用磁共振光谱评估兴奋性（谷氨酸/谷氨酰胺或Glx）和抑制性（γ-氨基丁酸或GABA）神经递质水平的差异。确诊DN并感觉症状阳性的糖尿病患者7例（男5例，女2例，平均年龄57.0±8.5岁）和年龄性别匹配的HC患者7例（平均年龄57.7±3.2岁）行3次特斯拉磁共振成像。定量测定右前脑岛和后脑岛、前扣带皮层和右丘脑的Glx和GABA水平。DN患者脑岛后部Glx水平显著高于HC， GABA水平显著低于HC （P分别为0.005和0.012）。该初步数据表明，与无疼痛的HC受试者相比，DN和阳性感觉症状患者的大脑中存在兴奋性/抑制性神经递质失衡。
To assess differences in excitatory (glutamate/glutamine or Glx) and inhibitory (γ-Aminobutyric acid or GABA) neurotransmitter levels using MR spectroscopy in pain processing regions of the brain in patients diabetic neuropathy (DN) and positive sensory symptoms and age-matched healthy control (HC) subjects. Seven diabetic patients (5 males, 2 females, mean age = 57.0 ± 8.5 years) with confirmed DN and positive sensory symptoms and 7 age and sex matched HC subjects (mean age = 57.7 ± 3.2 years) underwent 3 Tesla MR spectroscopy. Glx and GABA levels were quantified in the right anterior and posterior insula, anterior cingulate cortex and right thalamus. Mean Glx levels were significantly higher and mean GABA levels were significantly lower within the posterior insula in the DN patients compared to HC (P = 0.005 and 0.012 respectively). This pilot data demonstrates an excitatory/inhibitory neurotransmitter imbalance in the brain of in patients with DN and positive sensory symptoms compared to pain free HC subjects.
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影响因子：
3.3
作者：
Prescot A;Becerra L;Pendse G;Tully S;Jensen E;Hargreaves R;Renshaw P;Burstein R;Borsook D
通讯作者：
Borsook D
影响因子：
16.2
作者：
Albers JW;Herman WH;Pop-Busui R;Feldman EL;Martin CL;Cleary PA;Waberski BH;Lachin JM;Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications Research Group
通讯作者：
Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications Research Group
影响因子：
--
作者：
Valdes, Manuel;Collado, Antonio;Salamero, Manel
通讯作者：
Salamero, Manel
影响因子：
16.2
作者：
Selvarajah, Dinesh;Wilkinson, Iain D.;Tesfaye, Solomon
通讯作者：
Tesfaye, Solomon
影响因子：
2.3
作者：
Ritzwoller, Debra P.;Ellis, Jennifer L.;Sadosky, Alesia
通讯作者：
Sadosky, Alesia