The Efficacy of Percutaneous Patent Foramen Ovale Closure on Migraine: a Meta-Analysis of Randomized Controlled Trials and Observational Studies.
The Efficacy of Percutaneous Patent Foramen Ovale Closure on Migraine: a Meta-Analysis of Randomized Controlled Trials and Observational Studies.
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DOI：
10.1155/2021/6643266
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发表时间：
2021
影响因子：
--
通讯作者：
Zhao HR
中科院分区：
文献类型：
--
作者：
Zhang QQ;Lu JJ;Yan MY;Hu XW;Qin YR;Wang DP;Jiang JH;Fang Q;Zhao HR
卵圆孔未闭（PFO）闭合术对偏头痛是否有效存在争议。本文旨在通过随机对照试验和观察性研究评价PFO封堵术治疗偏头痛的疗效。 我们检索了截至2020年10月的PubMed、Embase和科克伦数据库，评价了偏头痛患者中PFO闭合与对照的比较，然后分别对所有RCT和观察性研究进行了荟萃分析。主要结果是（1）反应率：偏头痛完全停止;（2）每月偏头痛发作频率减少;（3）每月偏头痛天数减少。 确定了7项研究（3项RCT和4项观察性研究），包含887例偏头痛患者。(1)PFO封堵术治疗偏头痛的有效率在RCT亚组和观察性研究亚组中均显著高于对照组（OR 3.86，95%CI 1.35-11.04，P = 0.01; OR 8.28，95%CI 2.31-29.67，P = 0.001）。(2)在RCT亚组分析中，PFO封堵组偏头痛发作频率的降低高于对照组（平均差异（MD）= 0.57，95%CI 0.23-0.90，P = 0.0009）。(3)在RCT亚组分析中，PFO闭合组的偏头痛天数减少也高于对照组（MD = 1.33，95% CI 0.35-2.31，P = 0.008）。 PFO封堵术可能适用于偏头痛患者，尤其是有先兆的偏头痛患者，通过停止偏头痛或减少偏头痛发作和偏头痛天数。
Whether patent foramen ovale (PFO) closure is effective on migraine is controversial. This article was aimed at assessing the efficacy of PFO closure on migraine based on randomized controlled trials (RCTs) and observational studies. We searched PubMed, Embase, and Cochrane databases up to October 2020 evaluating PFO closure versus control in patients with migraine, then conducted a meta-analysis of all RCTs and observational studies, respectively. The main outcomes were (1) respond rate: complete cessation of migraine; (2) reduction in the frequency of migraine attacks per month; and (3) reduction in migraine days per month. Seven studies (3 RCTs and 4 observational studies), containing 887 migraine patients, were identified. (1) The respond rate of PFO closure on migraine was significantly higher than control group both in RCT subgroup and observational studies subgroup (OR 3.86, 95% CI 1.35-11.04, P = 0.01 in RCTs; OR 8.28, 95% CI 2.31-29.67, P = 0.001 in observational studies). (2) Reduction in frequency of migraine attacks was higher in PFO closure group compared with control group in the RCT subgroup analysis (mean difference (MD) = 0.57, 95% CI 0.23-0.90, P = 0.0009). (3) Reduction in migraine days was also higher in PFO closure group compared with control group in the RCT subgroup analysis (MD = 1.33, 95% CI 0.35-2.31, P = 0.008). PFO closure might be suitable for migraine patients, especially for migraine with aura, by cessation of migraine headaches or reducing migraine attacks and migraine days.
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影响因子：
11.3
作者：
Ben-Assa, Eyal;Rengifo-Moreno, Pablo;Palacios, Igor F.
通讯作者：
Palacios, Igor F.
影响因子：
3.3
作者：
Tepper, S. J.;Sheftell, F. D.;Bigal, M. E.
通讯作者：
Bigal, M. E.
影响因子：
5.7
作者：
Meier, Bernhard
通讯作者：
Meier, Bernhard
影响因子：
1.6
作者：
Elbadawi, Ayman;Barssoum, Kirolos;Saad, Marwan
通讯作者：
Saad, Marwan
影响因子：
2.5
作者：
Takagi, Hisato;Umemoto, Takuya
通讯作者：
Umemoto, Takuya