H2AFZ, RNF4 and NR4A1 loci are associated with boar semen quality by population association studies
H2AFZ, RNF4 and NR4A1 loci are associated with boar semen quality by population association studies
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根据群体关联研究，H2AFZ、RNF4 和 NR4A1 基因座与公猪精液质量相关
DOI：
10.1080/10495398.2018.1521825
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发表时间：
2018-12
影响因子：
3.7
通讯作者：
Li F
中科院分区：
文献类型：
--
作者：
Zhao L;Ma C;Song H;Feng Y;Li Y;Xia X;Li J;Li F
摘要精子发生是一个受多种基因调控的复杂过程。本研究根据猪精液品质性状在生精过程中的功能，筛选出了3个候选基因：H2 AFZ c.192 + 210-192 + 213delCGAT、RNF4 c.374 + 358 T >； C和NR4A1 c.956 + 796 A >； G，并对杜洛克猪(n = 185)、大白猪(n = 87)和长白猪(n = 49)的精液品质性状进行了关联分析。结果表明，在长白猪中， + C.192、 + 213delCGAT AA公猪的精子畸形率比AB公猪低1.52%(p <； 0.05)，在大白猪中，RNF4 c.374 + 358 TC公猪的精子密度(SCON)比CC公猪(p <； 0.05)高0.31× 108/ml， 4A1 c.956 + 796 A >； G在杜洛克猪和大白猪中与ASR有关，在大白猪和长白猪中与精子活力有关。本研究表明，H2AFZ、RNF4和NR4A1基因座是改良公猪精液品质性状的潜在分子标记。
Abstract Spermatogenesis is a complex process regulated by many genes. In this study, H2AFZ, RNF4 and NR4A1 genes were selected as candidate genes for boar semen quality traits based on their functions during spermatogenesis, and the associations of three loci (H2AFZ c.192 + 210–192 + 213delCGAT, RNF4 c.374 + 358 T > C and NR4A1 c.956 + 796 A > G) with sperm quality traits were analyzed in Duroc (n = 185), Large White (n = 87) and Landrace (n = 49) pig populations. The results showed H2AFZ c.192 + 210–192 + 213delCGAT AA boars produced 1.52% lower abnormal sperm rate (ASR) than AB boars in Landrace pigs (p < 0.05); RNF4 c.374 + 358 TC boars produced 0.31 × 108/ml higher sperm concentration (SCON) than CC boars (p < 0.05) in Large White pigs; NR4A1 c.956 + 796 A > G was associated with ASR in Duroc and Large White pigs and was associated with sperm motility (MOT) in Large White and Landrace pigs. This study indicated the H2AFZ, RNF4 and NR4A1 loci were the potential molecular markers for improving the semen quality traits in boars.
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影响因子：
44.1
作者：
Shi, YY;He, L
通讯作者：
He, L
影响因子：
2.5
作者：
Raffaela Pero;F. Lembo;P. Chieffi;G. Del Pozzo;M. Fedele;A. Fusco;C. Bruni;L. Chiariotti
通讯作者：
Raffaela Pero;F. Lembo;P. Chieffi;G. Del Pozzo;M. Fedele;A. Fusco;C. Bruni;L. Chiariotti
miR-762通过环指蛋白4（RNF4）基因促进猪未成熟支持细胞生长
影响因子：
4.6
作者：
Ma C;Song H;Yu L;Guan K;Hu P;Li Y;Xia X;Li J;Jiang S;Li F
通讯作者：
Li F
影响因子：
3.6
作者：
Gliozzi, T. M.;Turri, F.;Pizzi, F.
通讯作者：
Pizzi, F.
DOI：
10.1530/biosciprocs.15.005
发表时间：
2020-10
期刊：
Journal of reproduction and fertility. Supplement
影响因子：
--
作者：
W. Flowers
通讯作者：
W. Flowers