Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID).
Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID).
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DOI：
10.1136/bmjresp-2021-001049
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发表时间：
2021-09
影响因子：
4.1
通讯作者：
Jenkins RG
中科院分区：
文献类型：
--
作者：
Wild JM;Porter JC;Molyneaux PL;George PM;Stewart I;Allen RJ;Aul R;Baillie JK;Barratt SL;Beirne P;Bianchi SM;Blaikley JF;Brooke J;Chaudhuri N;Collier G;Denneny EK;Docherty A;Fabbri L;Gibbons MA;Gleeson FV;Gooptu B;Hall IP;Hanley NA;Heightman M;Hillman TE;Johnson SR;Jones MG;Khan F;Lawson R;Mehta P;Mitchell JA;Platé M;Poinasamy K;Quint JK;Rivera-Ortega P;Semple M;Simpson AJ;Smith D;Spears M;Spencer LG;Stanel SC;Thickett DR;Thompson AAR;Walsh SL;Weatherley ND;Weeks ME;Wootton DG;Brightling CE;Chambers RC;Ho LP;Jacob J;Piper Hanley K;Wain LV;Jenkins RG
COVID-19疫情已导致全球超过1亿例病例。英国有超过400万例病例，40万人入院，10万人死亡。许多COVID-19患者患有长期症状，主要是呼吸困难和疲劳，无论是否住院。早期数据表明，COVID-19的潜在严重长期后果是发生长期COVID-19相关间质性肺病（LC-ILD）。英国间质性肺疾病联盟（UKILD）将对COVID-19后疑似ILD患者进行纵向观察性研究。主要目的是确定感染后12个月的ILD患病率以及临床严重感染是否与ILD的严重程度相关。次要目的将确定决定ILD恢复或进展轨迹的临床、遗传、表观遗传和生化因素。数据将通过与住院后COVID平台研究和社区研究的联系获得。额外的子研究将进行深入的表型分析。肺泡功能障碍的氙MRI研究子研究将进行纵向氙肺泡气体转移和质子灌注MRI。COVID-19后间质性肺病E子研究将进行具有临床指征的支气管肺泡灌洗，并采集匹配的全血样本。评估包括探索性单细胞RNA和肺微生物组学分析、基因表达和表观遗传评估。所有参与研究均已获得适当的伦理批准。这项研究的结果将通过同行评审的期刊传播。本研究将确保确立LC-ILD的程度和后果，并制定缓解LC-ILD进展的策略。
The COVID-19 pandemic has led to over 100 million cases worldwide. The UK has had over 4 million cases, 400 000 hospital admissions and 100 000 deaths. Many patients with COVID-19 suffer long-term symptoms, predominantly breathlessness and fatigue whether hospitalised or not. Early data suggest potentially severe long-term consequence of COVID-19 is development of long COVID-19-related interstitial lung disease (LC-ILD). The UK Interstitial Lung Disease Consortium (UKILD) will undertake longitudinal observational studies of patients with suspected ILD following COVID-19. The primary objective is to determine ILD prevalence at 12 months following infection and whether clinically severe infection correlates with severity of ILD. Secondary objectives will determine the clinical, genetic, epigenetic and biochemical factors that determine the trajectory of recovery or progression of ILD. Data will be obtained through linkage to the Post-Hospitalisation COVID platform study and community studies. Additional substudies will conduct deep phenotyping. The Xenon MRI investigation of Alveolar dysfunction Substudy will conduct longitudinal xenon alveolar gas transfer and proton perfusion MRI. The POST COVID-19 interstitial lung DiseasE substudy will conduct clinically indicated bronchoalveolar lavage with matched whole blood sampling. Assessments include exploratory single cell RNA and lung microbiomics analysis, gene expression and epigenetic assessment. All contributing studies have been granted appropriate ethical approvals. Results from this study will be disseminated through peer-reviewed journals. This study will ensure the extent and consequences of LC-ILD are established and enable strategies to mitigate progression of LC-ILD.
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影响因子：
3.3
作者：
Chan HF;Stewart NJ;Norquay G;Collier GJ;Wild JM
通讯作者：
Wild JM
影响因子：
3.1
作者：
Jakubowski, Maciej;Turek-Jakubowska, Aleksandra;Doroszko, Adrian
通讯作者：
Doroszko, Adrian
影响因子：
64.8
作者：
Rendeiro AF;Ravichandran H;Bram Y;Chandar V;Kim J;Meydan C;Park J;Foox J;Hether T;Warren S;Kim Y;Reeves J;Salvatore S;Mason CE;Swanson EC;Borczuk AC;Elemento O;Schwartz RE
通讯作者：
Schwartz RE
影响因子：
8.3
作者：
Myall KJ;Mukherjee B;Castanheira AM;Lam JL;Benedetti G;Mak SM;Preston R;Thillai M;Dewar A;Molyneaux PL;West AG
通讯作者：
West AG
DOI：
10.1164/rccm.201607-1408oc
发表时间：
2017-06-15
影响因子：
24.7
作者：
Molyneaux, Philip L.;Willis-Owen, Saffron A. G.;Maher, Toby M.
通讯作者：
Maher, Toby M.