3D diffusion-weighted (129) Xe MRI for whole lung morphometry.
3D diffusion-weighted (129) Xe MRI for whole lung morphometry.
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DOI：
10.1002/mrm.26960
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发表时间：
2018-06
影响因子：
3.3
通讯作者：
Wild JM
中科院分区：
文献类型：
--
作者：
Chan HF;Stewart NJ;Norquay G;Collier GJ;Wild JM
采用3D多B-值129 mm弥散加权MRI（DW-MRI），在单次屏气中获得129 mm全肺形态测量值，并采用经验优化的弥散时间和压缩感知进行扫描加速。采集了前瞻性三倍欠采样3D多个B值超极化129 μ m DW-MRI数据集，并迭代扩散时间（Δ），以便根据拉伸指数模型（SEM）提供与3 He相当的扩散长度尺度（LmD）估计值。然后采用四倍欠采样方案实施经验优化的129 He扩散时间，并使用SEM推导的LmD和圆柱体模型（CM）推导的平均弦长（Lm），在5名健康志愿者、6名戒烟者和2名慢性阻塞性肺病患者的队列中，对3 He测量值进行前瞻性基准测试。平均129 He和3 He LmD之间的一致性良好（平均差异，2.2%）和Lm在经验优化的129 mm Δ = 8.5 ms时，在所有受试者中获得了（平均差异，1.1%）值。压缩感知有助于单次呼吸3D多个B值129 mm DW-MRI采集，在129 He Δ = 8.5 ms时的结果表明，129 He为SEM或CM的全肺形态测量标测提供了一种可行的替代3 He的方法。Magn Reson Med 79：2986-2995，2018。© 2017 The Authors Magnetic Resonance in Medicine出版由Wiley Periodicals，Inc.国际医学磁共振学会（International Society for Magnetic Resonance in Medicine）这是一个开放获取的条款下的知识共享署名许可证，允许使用，分发和复制在任何媒体上，只要原始作品是适当的引用。
To obtain whole lung morphometry measurements from 129Xe in a single breath‐hold with 3D multiple b‐value 129Xe diffusion‐weighted MRI (DW‐MRI) with an empirically optimized diffusion time and compressed sensing for scan acceleration. Prospective three‐fold undersampled 3D multiple b‐value hyperpolarized 129Xe DW‐MRI datasets were acquired, and the diffusion time (Δ) was iterated so as to provide diffusive length scale (LmD) estimates from the stretched exponential model (SEM) that are comparable to those from 3He. The empirically optimized 129Xe diffusion time was then implemented with a four‐fold undersampling scheme and was prospectively benchmarked against 3He measurements in a cohort of five healthy volunteers, six ex‐smokers, and two chronic obstructive pulmonary disease patients using both SEM‐derived LmD and cylinder model (CM)‐derived mean chord length (Lm). Good agreement between the mean 129Xe and 3He LmD (mean difference, 2.2%) and Lm (mean difference, 1.1%) values was obtained in all subjects at an empirically optimized 129Xe Δ = 8.5 ms. Compressed sensing has facilitated single‐breath 3D multiple b‐value 129Xe DW‐MRI acquisitions, and results at 129Xe Δ = 8.5 ms indicate that 129Xe provides a viable alternative to 3He for whole lung morphometry mapping with either the SEM or CM. Magn Reson Med 79:2986–2995, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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影响因子：
2.2
作者：
Sukstanskii, A. L.;Yablonskiy, D. A.
通讯作者：
Yablonskiy, D. A.
影响因子：
19.7
作者：
Quirk, James D.;Lutey, Barbara A.;Yablonskiy, Dmitriy A.
通讯作者：
Yablonskiy, Dmitriy A.
影响因子：
3.3
作者：
Sukstanskii, A. L.;Yablonskiy, D. A.
通讯作者：
Yablonskiy, D. A.
影响因子：
3.3
作者：
Kaushik, S. Sivaram;Cleveland, Zackary I.;Cofer, Gary P.;Metz, Gregory;Beaver, Denise;Nouls, John;Kraft, Monica;Auffermann, William;Wolber, Jan;McAdams, H. Page;Driehuys, Bastiaan
通讯作者：
Driehuys, Bastiaan
影响因子：
19.7
作者：
Kirby, Miranda;Svenningsen, Sarah;Parraga, Grace
通讯作者：
Parraga, Grace