Association of dietary magnesium intake with radiographic knee osteoarthritis: results from a population-based study.
Association of dietary magnesium intake with radiographic knee osteoarthritis: results from a population-based study.
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DOI：
10.1002/acr.21708
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发表时间：
2012-09
影响因子：
4.7
通讯作者：
He, Ka
中科院分区：
文献类型：
--
作者：
Qin, Bo;Shi, Xiaoyan;Samai, Peter S.;Renner, Jordan B.;Jordan, Joanne M.;He, Ka
目的：研究非裔美国人和高加索人男性和女性饮食镁(Mg)摄入量与膝关节骨关节炎(OA)的横断面相关性。约翰斯顿县骨关节炎项目(JOCOOA)的参与者对膝关节骨关节炎的存在进行了检查，定义为至少一个膝关节的Kellgren-Lawrence(K-L)分级至少为2级。采用集体食物频率问卷(FFQ)评估镁的摄入量。根据以前的文献，通过测试镁摄入量和选定因素的交互作用来探索效果修饰剂。采用标准能量调整法建立多元Logistic回归模型，估计镁摄入量与膝关节X线骨性关节炎的关系。在2112名调查对象中，膝关节骨关节炎患病率为36.27%。镁摄入量与X线片膝关节骨密度的关系受种族因素的影响(交互作用P=0.03)。在高加索人中观察到了相反的阈值关联。与最低五分之一的参与者相比，镁摄入量第二五分之一的参与者患膝骨性关节炎的相对几率降低了一半(OR：0.52；95%CI 0.34-0.79)；继续摄入镁并没有提供进一步的好处(趋势P=0.51)。在非裔美国人中没有观察到有统计学意义的关联。在高加索人中，饮食镁摄入量与膝骨性关节炎之间存在适度的相反的阈值关联，但在非裔美国人中并非如此。需要进一步的研究来证实结果，并阐明种族修饰的可能作用机制。
To examine the cross-sectional association between dietary magnesium (Mg) intake and the radiographic knee osteoarthritis (OA) among African-American and Caucasian men and women. The presence of radiographic knee OA was examined among participants from the Johnston County Osteoarthritis Project (JoCo OA) and was defined as Kellgren-Lawrence (K-L) grade of at least 2 in at least one knee. The Block Food Frequency Questionnaire (FFQ) was used to assess Mg intake. Effect modifiers were explored by testing interactions of Mg intake and selected factors based on previous literature. The multivariable logistic regression model with standard energy adjustment method was used to estimate the relation of Mg intake and radiographic knee OA. The prevalence of knee OA was 36.27% among 2112 participants. The relation of Mg intake and radiographic knee OA was found to be modified by race (P for interaction = 0.03). An inverse threshold association was observed among Caucasians. Comparing to those in the lowest quintile, the relative odds of radiographic knee OA was cut by half for participants in the second quintile of Mg intake (OR: 0.52; 95% CI 0.34–0.79); further Mg intake did not provide further benefits (P for trend = 0.51). A statistically significant association was not observed among African Americans. A modest inverse threshold association was found between dietary Mg intake and knee OA in Caucasians but not in African Americans. Further studies are needed to confirm the results and to elucidate the possible mechanisms of action for the racial modification.
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影响因子：
105.7
作者：
Danesh, J;Whincup, P;Pepys, MB
通讯作者：
Pepys, MB
影响因子：
--
作者：
Haywood, L;McWilliams, DF;Walsh, DA
通讯作者：
Walsh, DA
影响因子：
7
作者：
Allen, K. D.;Helmick, C. G.;Jordan, J. M.
通讯作者：
Jordan, J. M.
影响因子：
5
作者：
BLOCK, G;COYLE, LM;SCOPPA, SM
通讯作者：
SCOPPA, SM
DOI：
10.1080/07315724.2004.10719344
发表时间：
2004-02-01
影响因子：
3.5
作者：
Al-Delaimy, WK;Rimm, EB;Hu, FB
通讯作者：
Hu, FB