Increased cancer cell proliferation in prostate cancer patients with high levels of serum folate.
Increased cancer cell proliferation in prostate cancer patients with high levels of serum folate.
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DOI：
10.1002/pros.21346
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发表时间：
2011-09
期刊：
影响因子：
2.8
通讯作者：
O'Keefe, Denise S.
中科院分区：
文献类型：
--
作者：
Tomaszewski, Jeffrey J.;Cummings, Jessica L.;Parwani, Anil V.;Dhir, Rajiv;Mason, Joel B.;Nelson, Joel B.;Bacich, Dean J.;O'Keefe, Denise S.
最近的一项临床试验显示，叶酸补充剂与前列腺癌发病率增加有关。由于培养物中的肿瘤细胞直接对可用的叶酸产生反应而增殖，我们研究的目的是确定患者叶酸状态与前列腺癌患者肿瘤增殖能力之间是否存在类似的关系。在随机选择的87例接受前列腺癌手术的患者中测定血清叶酸和/或前列腺组织叶酸，并与亚组中的肿瘤增殖进行比较。空腹血清叶酸水平与前列腺肿瘤组织中叶酸含量呈正相关（n= 15; r= 0.577，p<0.03）。平均血清叶酸为62.6 nM [7.5-145.2 nM]，39.5%的患者使用含叶酸的补充剂（n=86）。前四分之一的患者血清叶酸水平高于82 nM，是认为足够水平的六倍。其中，48%的人报告没有使用补充剂。在50例Gleason 7疾病患者中，通过Ki 67染色测定的平均增殖指数在血清叶酸水平最高（117 ± 15 nM）和最低（18 ± 9 nM）五分位数患者的肿瘤中分别为6.17 ± 3.2%和0.86 ± 0.92%（p<0.0001）。在血清叶酸浓度较高的男性中，癌细胞增殖增加与补充叶酸后观察到的前列腺癌发病率增加一致。出乎意料的是，超过25%的患者血清叶酸水平超过6倍。这些男性中有近一半报告没有使用补充剂，这表明叶酸代谢改变和/或从强化食品中持续摄入叶酸。
A recent clinical trial revealed that folic acid supplementation is associated with an increased incidence of prostate cancer. As tumor cells in culture proliferate directly in response to available folic acid, the goal of our study was to determine if there is a similar relationship between patient folate status, and the proliferative capacity of tumors in men with prostate cancer. Serum folate and/or prostate tissue folate was determined in 87 randomly selected patients undergoing surgery for prostate cancer, and compared to tumor proliferation in a subset. Fasting serum folate levels were positively correlated with prostate tumor tissue folate content (n= 15; r= 0.577, p<0.03). Mean serum folate was 62.6 nM [7.5–145.2 nM], 39.5% of patients used supplements containing folic acid (n=86). The top quartile of patients had serum folates above 82 nM, six times the level considered adequate. Of these, 48% reported no supplement use. Among 50 patients with Gleason 7 disease, the mean proliferation index as determined by Ki67 staining was 6.17 ± 3.2% and 0.86 ± 0.92% in the tumors from patients in the highest (117 ± 15 nM) and lowest (18 ± 9 nM) quintiles for serum folate, respectively (p<0.0001). Increased cancer cell proliferation in men with higher serum folate concentrations is consistent with an increase in prostate cancer incidence observed with folate supplementation. Unexpectedly, more than 25% of patients had serum folate levels greater than 6-fold adequate. Nearly half of these men reported no supplement use, suggesting either altered folate metabolism and/or sustained consumption of folic acid from fortified foods.
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影响因子：
4.2
作者：
Ericson, Ulrika;Borgquist, Signe;Wirfalt, Elisabet
通讯作者：
Wirfalt, Elisabet
影响因子：
7.1
作者：
Bailey, Regan L.;Mills, James L.;Picciano, Mary Frances
通讯作者：
Picciano, Mary Frances
影响因子：
11.2
作者：
Yao V;Parwani A;Maier C;Heston WD;Bacich DJ
通讯作者：
Bacich DJ
影响因子：
3.4
作者：
Gunia, Sven;Albrecht, Knut;May, Matthias
通讯作者：
May, Matthias
影响因子：
23.4
作者：
Rubio, J;Ramos, D;Llombart-Bosch, A
通讯作者：
Llombart-Bosch, A