The biomechanics of wounds at physiologically relevant levels: Understanding skin's stress-shielding effect for the quantitative assessment of healing
The biomechanics of wounds at physiologically relevant levels: Understanding skin's stress-shielding effect for the quantitative assessment of healing
复制标题
生理相关水平伤口的生物力学：了解皮肤的应力屏蔽效应，用于愈合的定量评估
DOI：
10.1016/j.mtbio.2024.100963
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发表时间：
2024-01-17
影响因子：
8.2
通讯作者：
Crichton, Michael L.
中科院分区：
文献类型：
--
作者：
Medina-Lombardero, Sara;Bain, Connor;Charlton, Laura;Pellicoro, Antonella;Rocliffe, Holly;Cash, Jenna;Reuben, Robert;Crichton, Michael L.
关键词：
伤口是导致世界各地数十亿人生活质量下降的原因。他们的评估依赖于主观参数，这通常会延迟最佳治疗并导致医疗费用增加。在这项工作中，我们试图了解和量化不同愈合阶段（受伤后第1、3、7和14天）的伤口如何改变包含它们的组织的机械特性，以及如何在临床相关应变水平下测量这些特性，作为迈向定量伤口跟踪技术的一步。为了实现这一点，我们使用数字图像相关性和机械测试的伤口愈合的小鼠模型，以映射全球和局部组织应变。我们发现，当大量测量样本时，受伤皮肤与未受伤皮肤的弹性和粘弹性没有显著差异，大概是因为这些被皮肤的保护机制所掩盖，皮肤的保护机制重新分配施加的载荷以减轻高应力并减少组织损伤。通过测量局部应变值并观察它们形成的不同模式，可以建立组织愈合阶段（由损伤后时间和观察到的组织学特征确定）与整体机械行为之间的联系。重要的是，这些参数是从组织表面测量的，使用生理相关的菌株，而不增加组织的损伤。将这些方法应用于临床有可能有助于识别皮肤愈合问题，如过度炎症或随着时间的推移缺乏机械进展。弹性和粘弹性参数的增加、减少或缺乏变化可以指示伤口状态，从而最终导致改善的诊断结果。
Wounds are responsible for the decrease in quality of life of billions of people around the world. Their assessment relies on subjective parameters which often delays optimal treatments and results in increased healthcare costs. In this work, we sought to understand and quantify how wounds at different healing stages (days 1, 3, 7 and 14 post wounding) change the mechanical properties of the tissues that contain them, and how these could be measured at clinically relevant strain levels, as a step towards quantitative wound tracking technologies. To achieve this, we used digital image correlation and mechanical testing on a mouse model of wound healing to map the global and local tissue strains. We found no significant differences in the elastic and viscoelastic properties of wounded vs unwounded skin when samples were measured in bulk, presumably as these were masked by the protective mechanisms of skin, which redistributes the applied loads to mitigate high stresses and reduce tissue damage. By measuring local strain values and observing the distinct patterns they formed, it was possible to establish a connection between the healing phase of the tissue (determined by the time post-injury and the observed histological features) and the overall mechanical behaviour. Importantly, these parameters were measured from the surface of the tissue, using physiologically relevant strains without increasing the tissue's damage. Adaptations of these approaches for clinical use have the potential to aid in the identification of skin healing problems, such as excessive inflammation or lack of mechanical progression over time. An increase, decrease, or lack of change in the elasticity and viscoelasticity parameters, can be indicative of wound state, thus ultimately leading to improved diagnostic outcomes.
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