Stressful life events and accelerated biological aging over time in youths.
Stressful life events and accelerated biological aging over time in youths.
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DOI：
10.1016/j.psyneuen.2023.106058
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发表时间：
2023-05
影响因子：
3.7
通讯作者：
McLaughlin, Katie A.
中科院分区：
文献类型：
--
作者：
Sumner, Jennifer A.;Gao, Xu;Gambazza, Simone;Dye, Christian K.;Colich, Natalie L.;Baccarelli, Andrea A.;Uddin, Monica;McLaughlin, Katie A.
在童年和青春期经历逆境，包括压力生活事件（SLE），可能会加速发育速度，导致不良的心理和身体健康。然而，大多数关于青少年不良早期经历和生物衰老（BA）的研究都依赖于横截面设计。我们对 171 名青少年进行了大约 2 年的随访，研究了随访期间的 SLE 是否预测了两个 BA 指标（表观遗传年龄和 Tanner 阶段）的变化率。我们还调查了 BA 的变化率是否与抑郁症状随时间的变化相关。基线时 8-16 岁的青少年自我报告了基线和随访时的坦纳阶段和抑郁症状，并在两次评估中提供了唾液样本进行 DNA 检测。 Horvath 表观遗传年龄估计源自使用 Illumina EPIC 阵列测量的 DNA 甲基化数据。在后续行动中，对青少年和护理人员进行了情境威胁访谈，以评估青少年过去一年的 SLE 经历。独立评级团队对访谈进行客观编码，生成 SLE 影响评分，反映上一年发生的所有 SLE 的严重程度。 BA指标的变化率被操作为表观遗传年龄或坦纳阶段的变化，作为评估之间时间的函数。随访期间较高的客观 SLE 影响评分与较大的表观遗传年龄变化率相关（β=0.21，p=.043）。此外，在基线时 Tanner 分期较低但不较高的青少年中，SLE 影响评分与 Tanner 分期变化率呈正相关（基线 Tanner 分期 x SLE 影响评分交互作用：β=−0.21，p=.011）。表观遗传年龄的较大变化率也与随访时较高的抑郁症状水平相关，调整基线症状（β=0.15，p=.043）。当调整上皮（口腔）细胞比例时，与表观遗传年龄的关联相似，尽管略有减弱。尽管许多针对青少年的研究都集中在早期逆境的严重经历上，但我们证明，青春期更常见的 SLE 也可能有助于加速 BA。需要进一步研究来了解 BA 指标变化对健康的长期影响。
Experiencing adversity in childhood and adolescence, including stressful life events (SLEs), may accelerate the pace of development, leading to adverse mental and physical health. However, most research on adverse early experiences and biological aging (BA) in youths relies on cross-sectional designs. In 171 youths followed for approximately 2 years, we examined if SLEs over follow-up predicted rate of change in two BA metrics: epigenetic age and Tanner stage. We also investigated if rate of change in BA was associated with changes in depressive symptoms over time. Youths aged 8–16 years at baseline self-reported Tanner stage and depressive symptoms at baseline and follow-up and provided saliva samples for DNA at both assessments. Horvath epigenetic age estimates were derived from DNA methylation data measured with the Illumina EPIC array. At follow-up, contextual threat interviews were administered to youths and caregivers to assess youths’ experiences of past-year SLEs. Interviews were objectively coded by an independent rating team to generate a SLE impact score, reflecting the severity of all SLEs occurring over the prior year. Rate of change in BA metrics was operationalized as change in epigenetic age or Tanner stage as a function of time between assessments. Higher objective SLE impact scores over follow-up were related to a greater rate of change in epigenetic age (β=0.21, p=.043). Additionally, among youths with lower—but not higher—Tanner stage at baseline, there was a positive association of SLE impact scores with rate of change in Tanner stage (Baseline Tanner Stage x SLE Impact Score interaction: β=−0.21, p=.011). A greater rate of change in epigenetic age was also associated with higher depressive symptom levels at follow-up, adjusting for baseline symptoms (β=0.15, p=.043). Associations with epigenetic age were similar, although slightly attenuated, when adjusting for epithelial (buccal) cell proportions. Whereas much research in youths has focused on severe experiences of early adversity, we demonstrate that more commonly experienced SLEs during adolescence may also contribute to accelerated BA. Further research is needed to understand the long-term consequences of changes in BA metrics for health.
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影响因子：
6.6
作者：
Beydoun, May A.;Hossain, Sharmin;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.
影响因子：
5.9
作者：
Colich, Natalie L.;McLaughlin, Katie A.
通讯作者：
McLaughlin, Katie A.
青春期女孩 DNA 甲基化年龄加速：与昼夜皮质醇升高和海马体积减少有关。
影响因子：
6.8
作者：
Davis EG;Humphreys KL;McEwen LM;Sacchet MD;Camacho MC;MacIsaac JL;Lin DTS;Kobor MS;Gotlib IH
通讯作者：
Gotlib IH
DOI：
10.1146/annurev-clinpsy-032816-045054
发表时间：
2018-05-07
影响因子：
18.4
作者：
Epel ES;Prather AA
通讯作者：
Prather AA
影响因子：
5
作者：
Callaghan BL;Tottenham N
通讯作者：
Tottenham N