The Stress Acceleration Hypothesis: Effects of early-life adversity on emotion circuits and behavior.
The Stress Acceleration Hypothesis: Effects of early-life adversity on emotion circuits and behavior.
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DOI：
10.1016/j.cobeha.2015.11.018
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发表时间：
2016-02
影响因子：
5
通讯作者：
Tottenham N
中科院分区：
文献类型：
--
作者：
Callaghan BL;Tottenham N
早期经历对整个生命周期心理健康的重要性是公认的。特别是，不良的生活经历和精神疾病之间有很强的联系。然而，相对于评估成年人结果的研究，评估发展过程中经历逆境的早期表现的研究要少得多。这种发展研究的缺乏限制了对逆境与精神疾病联系机制的理解。在这一领域的研究中采用发展的方法将使人们更深入地了解将逆境与整个生命周期的不良情绪功能联系在一起的因素。在这篇评论中，我们专注于最近的研究结果，在心理健康和早期逆境的检查中使用了发展的方法。这些研究值得注意的是，在众多物种中，他们都认为早期的逆境会导致大脑中情感回路的加速成熟，以及这些区域支持的行为。我们认为这些“压力加速”效应是早期系统适应的证据。
The importance of early experiences for mental health across the lifespan is well recognized. In particular, there is a strong association between adverse caregiving experiences and mental illness. However, relative to studies assessing outcomes in adults, there are far fewer studies assessing the earlier emerging manifestations of caregiving adversity during development. This lack of developmental research limits an understanding of the mechanisms that link adversity with mental illness. Adoption of a developmental approach to research in this field will yield greater insights into the factors that tie adversity to poor emotion function across a lifespan. In this review, we focus on recent findings that have used a developmental approach in the examination of mental health and early adversity. These studies are notable in that, across numerous species, they converge on the idea that early adversity leads to accelerated maturation of emotion circuits in the brain and in the behaviors supported by these regions. We propose that these ‘stress acceleration’ effects are evidence of early system adaptation.
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DOI：
10.1523/jneurosci.2021-06.2006
发表时间：
2006-09-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kalisch R;Korenfeld E;Stephan KE;Weiskopf N;Seymour B;Dolan RJ
通讯作者：
Dolan RJ
影响因子：
7.2
作者：
Frankenhuis, Willem E.;de Weerth, Carolina
通讯作者：
de Weerth, Carolina
影响因子：
1.9
作者：
Callaghan, Bridget L.;Richardson, Rick
通讯作者：
Richardson, Rick
影响因子：
1.9
作者：
Cowan, Caitlin S. M.;Callaghan, Bridget L.;Richardson, Rick
通讯作者：
Richardson, Rick
影响因子：
7.2
作者：
Belsky, Jay
通讯作者：
Belsky, Jay