From Stem Cells to Bone-Forming Cells.
From Stem Cells to Bone-Forming Cells.
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DOI：
10.3390/ijms22083989
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发表时间：
2021-04-13
影响因子：
5.6
通讯作者：
Riminucci M
中科院分区：
文献类型：
--
作者：
Donsante S;Palmisano B;Serafini M;Robey PG;Corsi A;Riminucci M
骨的形成在胚胎发育阶段接近尾声时开始，并在整个生命过程中持续到骨的建模和生长、重塑，以及需要时的再生。骨形成细胞，传统上被称为成骨细胞，它产生、组装和控制I型胶原富集骨基质的矿化，同时参与其他细胞过程的调节，如破骨细胞的形成和代谢活动，如磷酸盐稳态。成骨细胞是由来自不同胚胎规格的不同骨骼干细胞群产生的，这些干细胞在多种调节因子的控制下在出生前和/或成年骨骼中运行。在这篇综述中，我们简要定义了成骨细胞的细胞特性和功能，并讨论了迄今为止已鉴定的成骨细胞的主要群体。我们还提供了通过对小鼠模型和人类遗传性骨骼疾病的研究来评估成骨谱系的规范所涉及的长期已知和新近认识的调控途径和机制的例子。
Bone formation starts near the end of the embryonic stage of development and continues throughout life during bone modeling and growth, remodeling, and when needed, regeneration. Bone-forming cells, traditionally termed osteoblasts, produce, assemble, and control the mineralization of the type I collagen-enriched bone matrix while participating in the regulation of other cell processes, such as osteoclastogenesis, and metabolic activities, such as phosphate homeostasis. Osteoblasts are generated by different cohorts of skeletal stem cells that arise from different embryonic specifications, which operate in the pre-natal and/or adult skeleton under the control of multiple regulators. In this review, we briefly define the cellular identity and function of osteoblasts and discuss the main populations of osteoprogenitor cells identified to date. We also provide examples of long-known and recently recognized regulatory pathways and mechanisms involved in the specification of the osteogenic lineage, as assessed by studies on mice models and human genetic skeletal diseases.
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影响因子：
--
作者：
Florencio-Silva R;Sasso GR;Sasso-Cerri E;Simões MJ;Cerri PS
通讯作者：
Cerri PS
影响因子：
64.5
作者：
Baryawno, Ninib;Przybylski, Dariusz;Scadden, David T.
通讯作者：
Scadden, David T.
影响因子：
6.2
作者：
Corsi, A;Collins, MT;Bianco, P
通讯作者：
Bianco, P
影响因子：
11.8
作者：
Bialek, P;Kern, B;Karsenty, G
通讯作者：
Karsenty, G
影响因子：
4.1
作者：
Berendsen AD;Olsen BR
通讯作者：
Olsen BR