Eph/Ephrin-Based Protein Complexes: The Importance of cis Interactions in Guiding Cellular Processes.
Eph/Ephrin-Based Protein Complexes: The Importance of cis Interactions in Guiding Cellular Processes.
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DOI：
10.3389/fmolb.2021.809364
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发表时间：
2021
影响因子：
5
通讯作者：
Cornelison DDW
中科院分区：
文献类型：
--
作者：
Cecchini A;Cornelison DDW
虽然细胞内信号转导通常被认为是一个线性过程，通过跨膜受体将刺激从细胞外部传递到细胞内部，但与其他膜相关蛋白的相互作用往往是其成功的关键。这些分子通过顺式（在同一膜内）与主要效应物形成复合物在介导信号传导中发挥关键作用，特别是在肿瘤发生的背景下。这些次级效应物可能通过介导受体-配体结合、招募分子伙伴形成多蛋白复合物或差异信号转导结果来促进成功的信号转导。Eph/ephrin （Eph和EphB受体酪氨酸激酶及其配体ephrin- a和ephrin- b）是一个信号家族，其接触介导的活性经常被细胞表面的横向相互作用调节。通过顺式异型相互作用，这些分子可以促进多种细胞活动，包括一些互斥的活动（细胞增殖和细胞分化，或粘附和迁移）。由于它们在大多数组织中广泛表达，并且在类内和类间混杂结合，因此细胞对Eph:ephrin相互作用的反应在细胞类型之间是高度可变的，并且依赖于结合发生的细胞环境。在这篇综述中，我们将讨论顺式分子在细胞膜上的相互作用，重点讨论它们在调节Eph/ephrin信号传导中的作用。
Although intracellular signal transduction is generally represented as a linear process that transmits stimuli from the exterior of a cell to the interior via a transmembrane receptor, interactions with additional membrane-associated proteins are often critical to its success. These molecules play a pivotal role in mediating signaling via the formation of complexes in cis (within the same membrane) with primary effectors, particularly in the context of tumorigenesis. Such secondary effectors may act to promote successful signaling by mediating receptor-ligand binding, recruitment of molecular partners for the formation of multiprotein complexes, or differential signaling outcomes. One signaling family whose contact-mediated activity is frequently modulated by lateral interactions at the cell surface is Eph/ephrin (EphA and EphB receptor tyrosine kinases and their ligands ephrin-As and ephrin-Bs). Through heterotypic interactions in cis, these molecules can promote a diverse range of cellular activities, including some that are mutually exclusive (cell proliferation and cell differentiation, or adhesion and migration). Due to their broad expression in most tissues and their promiscuous binding within and across classes, the cellular response to Eph:ephrin interaction is highly variable between cell types and is dependent on the cellular context in which binding occurs. In this review, we will discuss interactions between molecules in cis at the cell membrane, with emphasis on their role in modulating Eph/ephrin signaling.
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DOI：
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发表时间：
2015-01-01
期刊：
Development (Cambridge, England)
影响因子：
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作者：
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DOI：
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发表时间：
2017-01-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
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