Elevated levels of adiponectin and other cytokines in drug naïve, first episode schizophrenia patients with normal weight
Elevated levels of adiponectin and other cytokines in drug naïve, first episode schizophrenia patients with normal weight
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体重正常、未曾用药的首发精神分裂症患者脂联素和其他细胞因子水平升高
DOI：
10.1016/j.schres.2013.07.044
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发表时间：
2013-10
影响因子：
4.5
通讯作者：
Douglas Ziedonis
中科院分区：
文献类型：
--
作者：
Luxian Lv;Xiaoduo Fan;Xinwen Song;Jianjiang Zhang;Wei Zhang;Xue Li;Jinsong Gao;Amy Harrington;Douglas Ziedonis
目的：检测体重正常的初治首发精神分裂症患者脂联素（APN）等细胞因子水平及机体代谢情况。方法纳入96例体重正常的初治首发精神分裂症患者（SZ组），60例正常体重健康者（对照组），60例超重或肥胖但其他健康者（肥胖组）。使用酶联免疫吸附测定（ELISA）测量白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和APN的血清水平。使用葡萄糖氧化酶来测量血浆葡萄糖水平。采用酶比色法测定脂质水平。结果SZ组和肥胖组血清IL-1β、IL-6和TNF-α水平均显着高于对照组（p<0.001）。 SZ 组和肥胖组之间这些细胞因子没有显着差异 (p's > 0.05)。此外，与对照组相比，SZ 组的 APN 水平显着较高（p < 0.001），而肥胖组的 APN 水平显着较低（p < 0.01）。此外，SZ 组内 APN 水平与其他细胞因子水平之间存在显着的正相关关系（p < 0.05）；相比之下，肥胖组内 APN 水平与其他细胞因子水平之间存在显着的负相关关系 (p < 0.05)。与其他两组相比，肥胖组的空腹血清葡萄糖、LDL、甘油三酯和总胆固醇水平显着升高，而空腹血清HDL水平显着降低（p<0.01）。对照组和 SZ 组之间的任何代谢参数均无显着差异 (p's > 0.05)。 结论 体重正常的初治首发精神分裂症患者似乎表现出上调的炎症状态，如 IL-1β、IL-6 和 TNF-α 水平升高所反映。 APN 可能在该患者群体中发挥独特的促炎作用。讨论了这些发现对精神分裂症发病机制和代谢问题的脆弱性的影响。
ObjectiveThe study was to examine the levels of adiponectin (APN) and other cytokines, and body metabolism in drug naïve, first episode schizophrenia patients with normal weight.MethodsNinety-six drug naïve, first episode schizophrenia patients with normal weight (SZ group), 60 healthy individuals with normal weight (control group), and 60 overweight or obese but otherwise healthy individuals (obesity group) were enrolled in the study. Serum levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and APN were measured using enzyme linked immunosorbent assay (ELISA). Glucose oxidase was used to measure plasma glucose level. Lipid levels were measured using the enzymatic colorimetric method.ResultsSerum levels of IL-1β, IL-6 and TNF-α in both the SZ group and the obesity group were significantly higher than those in the control group (p's < 0.001). There were no significant differences between the SZ group and the obesity group on those cytokines (p's > 0.05). In addition, the levels of APN were significantly higher in the SZ group (p < 0.001), and significantly lower in the obesity group (p < 0.01) compared with the control group. Further, there were significant positive relationships between levels of APN and levels of other cytokines within the SZ group (p's < 0.05); in contrast, there were significant negative relationships between levels of APN and levels of other cytokines within the obesity group (p's < 0.05). Fasting serum levels of glucose, LDL, triglycerides and total cholesterol were significantly higher, and fasting serum levels of HDL were significantly lower in the obesity group compared with the other two groups (p's < 0.01). There were no significant differences in any of the metabolic parameters between the control group and the SZ group (p's > 0.05).ConclusionsDrug naïve, first episode schizophrenia patients with normal weight seem to present an up-regulated inflammatory status as reflected by elevated levels of IL-1β, IL-6, and TNF-α. APN may play a unique pro-inflammatory role in this patient population. Implications of the findings in relation to the pathogenesis of schizophrenia and the vulnerability for metabolic problems were discussed.
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DOI：
--
发表时间：
2004
期刊：
Biomedical and environmental sciences : BES
影响因子：
--
作者：
Chunming Chen;F. Lu
通讯作者：
Chunming Chen;F. Lu
DOI：
--
发表时间：
2001-06
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
D. B. Allison;D. Casey
通讯作者：
D. B. Allison;D. Casey
DOI：
10.4088/jcp.v65n0710
发表时间：
2004-07
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
X. Zhang;D. Zhou;L. Cao;P. Zhang;G. Wu;Y. Shen
通讯作者：
X. Zhang;D. Zhou;L. Cao;P. Zhang;G. Wu;Y. Shen
影响因子：
2.7
作者：
Liao, Wenqiang;Yu, Changan;Campell, William
通讯作者：
Campell, William
影响因子：
3.7
作者：
Beumer, Wouter;Drexhage, Roosmarijn C.;Cohen, Dan
通讯作者：
Cohen, Dan