Transcriptional regulation of long-term memory in the marine snail Aplysia.
Transcriptional regulation of long-term memory in the marine snail Aplysia.
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在海洋蜗牛垂直腹腔中对长期记忆的转录调节。
DOI：
10.1186/1756-6606-1-3
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发表时间：
2008-06-17
期刊：
影响因子：
3.6
通讯作者：
Kaang BK
中科院分区：
文献类型：
--
作者：
Lee YS;Bailey CH;Kandel ER;Kaang BK
虽然短期记忆的诱导只涉及对结构性表达的先前存在的蛋白质的共价修饰，但长期记忆的形成需要基因表达、新的RNA和新的蛋白质合成。在细胞水平上，转录调控被认为是启动和维持长期突触促进(LTF)所必需的一系列分子步骤的起点。参与长期记忆过程的转录调控的核心分子特征在海兔、果蝇和小鼠中进化上是保守的，表明环状AMP反应元件结合蛋白(CREB)与不同的转录因子组合一起作用的基因调控对多种形式的长期记忆的表达至关重要。在海洋蜗牛海兔中，长期记忆储存的分子机制已经被广泛地研究在已识别的感觉神经元和退鳃反射的运动神经元之间的单突触联系中。一个尾部电击或一个脉冲的5-羟色胺(5-HT)是尾部电击释放的一种调节性递质，由cAMP依赖的蛋白激酶介导的瞬时易化作用导致感觉神经元的共价修饰，导致递质释放的增强和突触连接的加强，持续几分钟。相反，重复脉冲5-羟色胺(5-HT)可诱导持续超过24小时的转录和翻译依赖的长时程增强(LTF)，并触发突触前感觉神经元中一系列转录因子的激活，包括ApCREB1、ApCREB2和APC/EBP。此外，我们最近发现了新的转录因子，可以调节APC/EBP的表达，也参与了LTF的表达。在这篇综述中，我们研究了这些转录因子在不同刺激模式诱导的LTF巩固过程中的作用。
Whereas the induction of short-term memory involves only covalent modifications of constitutively expressed preexisting proteins, the formation of long-term memory requires gene expression, new RNA, and new protein synthesis. On the cellular level, transcriptional regulation is thought to be the starting point for a series of molecular steps necessary for both the initiation and maintenance of long-term synaptic facilitation (LTF). The core molecular features of transcriptional regulation involved in the long-term process are evolutionally conserved in Aplysia, Drosophila, and mouse, and indicate that gene regulation by the cyclic AMP response element binding protein (CREB) acting in conjunction with different combinations of transcriptional factors is critical for the expression of many forms of long-term memory. In the marine snail Aplysia, the molecular mechanisms that underlie the storage of long-term memory have been extensively studied in the monosynaptic connections between identified sensory neuron and motor neurons of the gill-withdrawal reflex. One tail shock or one pulse of serotonin (5-HT), a modulatory transmitter released by tail shocks, produces a transient facilitation mediated by the cAMP-dependent protein kinase leading to covalent modifications in the sensory neurons that results in an enhancement of transmitter release and a strengthening of synaptic connections lasting minutes. By contrast, repeated pulses of 5-hydroxytryptamine (5-HT) induce a transcription- and translation-dependent long-term facilitation (LTF) lasting more than 24 h and trigger the activation of a family of transcription factors in the presynaptic sensory neurons including ApCREB1, ApCREB2 and ApC/EBP. In addition, we have recently identified novel transcription factors that modulate the expression of ApC/EBP and also are critically involved in LTF. In this review, we examine the roles of these transcription factors during consolidation of LTF induced by different stimulation paradigms.
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DOI：
10.1073/pnas.1834280100
发表时间：
2003-09-02
影响因子：
11.1
作者：
Bourtchouladze, R;Lidge, R;Tully, T
通讯作者：
Tully, T
影响因子：
64.8
作者：
DASH, PK;HOCHNER, B;KANDEL, ER
通讯作者：
KANDEL, ER
影响因子：
3.8
作者：
CEDAR, H;SCHWARTZ, JH;KANDEL, ER
通讯作者：
KANDEL, ER
影响因子：
64.5
作者：
BOURTCHULADZE, R;FRENGUELLI, B;SILVA, AJ
通讯作者：
SILVA, AJ
影响因子：
64.5
作者：
Bartsch, D;Ghirardi, M;Kandel, ER
通讯作者：
Kandel, ER