Neutropenia during the First Cycle of Induction Chemotherapy Is Prognostic for Poor Survival in Locoregionally Advanced Nasopharyngeal Carcinoma: A Real-World Study in an Endemic Area.
Neutropenia during the First Cycle of Induction Chemotherapy Is Prognostic for Poor Survival in Locoregionally Advanced Nasopharyngeal Carcinoma: A Real-World Study in an Endemic Area.
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诱导化疗第一个周期期间的中性粒细胞减少症是局部晚期鼻咽癌生存不良的预后：流行地区的真实世界研究
DOI：
10.4143/crt.2017.255
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发表时间：
2018-07
影响因子：
4.6
通讯作者：
Ma J
中科院分区：
文献类型：
--
作者：
Xu C;Yang SP;Zhang Y;Tang LL;Zhou GQ;Liu X;Mao YP;Guo R;Li WF;Chen L;Lin AH;Sun Y;Ma J
Purpose The purpose of this study was to investigate the effect of neutropenia during the first cycle of induction chemotherapy (IC-1) on survival in locoregionally advanced nasopharyngeal carcinoma (LANPC). Materials and Methods Eligible patients (n=545) with LANPC receiving IC+concurrent chemoradiotherapy were included. Based on nadir neutrophil afterIC-1, all patientswere categorized into three groups: no/grade 1-2/grade 3-4 neutropenia. Five-year overall survival (OS) and disease-free survival (DFS) were compared between groups and subgroups stratified by IC regimen. We also explored the occurrence of IC-1–induced myelosuppression events and the minimal value of post-treatment neutrophil-to-lymphocyte ratio (post-NLRmin). Univariate/multivariate analyses were performed to investigate the effect of IC-1–induced neutropenia, timing of neutropenia, number of myelosuppression events, and high post-NLRmin on OS/DFS. Results Grade 1-2/grade 3-4 neutropeniawere associatedwith poorer OS/DFS than no neutropenia (all p < 0.05); OS/DFS were not significantly different between patients experiencing grade 1-2 vs. 3-4 neutropenia. Neutropenia had no significant effect on OS/DFS in patients receiving docetaxel–cisplatin–5-fluorouracil (TPF). Grade 1-2 (grade 3-4) neutropenia negatively influenced OS/DFS in patients receiving cisplatin–5-fluorouracil (PF) (PF and docetaxel–cisplatin [TP]; all p < 0.05). Neutropenia, two/three myelosuppression events, and high post-NLRmin (≥ 1.33) was most frequent on days 5-10, second and third week of IC-1, respectively. After adjustment for covariates, IC-1–induced neutropenia, two/three myelosuppression events, and post-NLRmin ≥ 1.33were validated as negative predictors of OS/DFS (all p < 0.05); timing of neutropenia had no significant effect. Conclusion Occurrence of neutropenia, number of myelosuppression events, and high post-NLRmin during PF/TP IC-1 have prognostic value for poor survival in LANPC.
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影响因子：
1.8
作者：
Neyeloff JL;Fuchs SC;Moreira LB
通讯作者：
Moreira LB
DOI：
10.1002/hed.24224
发表时间：
2016-04-01
影响因子：
2.9
作者：
Sun, Wei;Zhang, Linli;Hu, Guoqing
通讯作者：
Hu, Guoqing
影响因子：
2.5
作者：
Miyoshi, Norikatsu;Yano, Masahiko;Imaoka, Shingi
通讯作者：
Imaoka, Shingi
影响因子：
--
作者：
An, Xin;Ding, Pei-Rong;Li, Yu-Hong
通讯作者：
Li, Yu-Hong
基于第8版UICC/AJCC分期系统建立列线图并应用以筛选诱导化疗加同步放化疗获益的鼻咽癌患者
影响因子：
4.8
作者：
Xu, Cheng;Chen, Yu-Pei;Ma, Jun
通讯作者：
Ma, Jun