Primary structure of the α-subunit of transducin and its relationship to ras proteins
Primary structure of the α-subunit of transducin and its relationship to ras proteins
复制标题
转导蛋白α亚基的一级结构及其与ras蛋白的关系
作者：
T. Tanabe;T. Nukada;Y. Nishikawa;K. Sugimoto;Harukazu Suzuki;Hideo Takahashi;M. Noda;T. Haga;A. Ichiyama;K. Kangawa;N. Minamino;H. Matsuo;S. Numa
一组膜相关鸟嘌呤核苷酸结合蛋白（G 蛋白）对于将细胞表面受体产生的信号转导为细胞功能和代谢的变化至关重要。这些蛋白质是由 α、β 和 γ 三个亚基组成的复合物。 α-亚基负责结合鸟嘌呤核苷酸，似乎是每种蛋白质的特征。转导蛋白是该蛋白家族的一员，通过将光解视紫红质的信号与环 GMP 磷酸二酯酶 2 的激活相结合来介导视觉转导。我们现在已经克隆并测序了编码牛视网膜转导蛋白α亚基的互补DNA，并由此推导出完整的氨基酸序列。转导蛋白α亚基与ras基因产物共享多个同源氨基酸序列。同源片段主要对应于被认为涉及ras蛋白的鸟嘌呤核苷酸结合和GTP酶活性的区域以及转导蛋白α亚基的ADP-核糖基化位点。
A group of membrane-associated guanine nucleotide binding proteins (G-proteins) are essential for transducing signals generated at cell-surface receptors into changes in cellular function and metabolism1. These proteins are a complex of three subunits designated α, β and γ. The α-subunit is responsible for binding guanine nucleotides and seems to be characteristic of each protein. Transducin, a member of this protein family, mediates visual transduction by coupling the signal of photolysed rhodopsin with activation of a cyclic GMP phosphodiesterase2. We have now cloned and sequenced the complementary DNA encoding the α-subunit of bovine retinal transducin and from this we have deduced the complete amino-acid sequence. The transducin α-subunit shares several homologous amino-acid sequences with ras gene products. The homologous segments correspond mostly to the regions thought to be involved in the guanine nucleotide binding and GTPase activity of ras proteins and to the ADP-ribosylation sites of the transducin α-subunit.
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拉希德大鼠肉瘤病毒癌基因的核苷酸序列：新突变。
DOI：
10.1126/science.6344220
发表时间：
1983
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Rasheed,S;Norman,GL;Heidecker,G
通讯作者：
Heidecker,G
胰岛激活蛋白对转导蛋白进行 ADP 核糖基化。
DOI：
--
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Manning,DR;Fraser,BA;Kahn,RA;Gilman,AG
通讯作者：
Gilman,AG
霍乱毒素 ADP 核糖基化位点的视网膜转导蛋白的氨基酸序列。
DOI：
--
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
VanDop,C;Tsubokawa,M;Bourne,HR;Ramachandran,J
通讯作者：
Ramachandran,J
影响因子：
56.9
作者：
TSUCHIDA, N;RYDER, T;OHTSUBO, E
通讯作者：
OHTSUBO, E