Modulating RNA structure and catalysis: lessons from small cleaving ribozymes.
Modulating RNA structure and catalysis: lessons from small cleaving ribozymes.
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DOI：
10.1007/s00018-009-0124-1
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发表时间：
2009-12
影响因子：
8
通讯作者：
Perreault, Jean-Pierre
中科院分区：
文献类型：
--
作者：
Reymond, Cedric;Beaudoin, Jean-Denis;Perreault, Jean-Pierre
RNA是生命中的关键分子，了解其结构/功能关系是更全面地理解分子生物学的关键一步。尽管它们正确折叠所需的大部分信息都包含在它们的一级序列中，但我们到目前为止还无法准确预测RNA物种的折叠途径和活性三级结构。在解决这些问题时，核酶是值得研究的有趣分子，因为它们结构上的任何修改通常都反映在它们的催化性能上。从天然的、自切割的RNA基序中衍生的小核酶的结构、折叠途径和调控方面的最新研究进展，对今天这一领域的知识做出了重要贡献。
RNA is a key molecule in life, and comprehending its structure/function relationships is a crucial step towards a more complete understanding of molecular biology. Even though most of the information required for their correct folding is contained in their primary sequences, we are as yet unable to accurately predict both the folding pathways and active tertiary structures of RNA species. Ribozymes are interesting molecules to study when addressing these questions because any modifications in their structures are often reflected in their catalytic properties. The recent progress in the study of the structures, the folding pathways and the modulation of the small ribozymes derived from natural, self-cleaving, RNA motifs have significantly contributed to today’s knowledge in the field.
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影响因子：
14.9
作者：
Bergeron LJ;Perreault JP
通讯作者：
Perreault JP
影响因子：
64.8
作者：
BUZAYAN, JM;GERLACH, WL;BRUENING, G
通讯作者：
BRUENING, G
影响因子：
14.9
作者：
Ananvoranich, S;Lafontaine, DA;Perreault, JP
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Perreault, JP
影响因子：
15
作者：
Canny, MD;Jucker, FM;Pardi, A
通讯作者：
Pardi, A
影响因子：
64.8
作者：
CHOWRIRA, BM;BERZALHERRANZ, A;BURKE, JM
通讯作者：
BURKE, JM