Asymmetric connectivity reduction and its relationship to "HAROLD" in aging brain.
Asymmetric connectivity reduction and its relationship to "HAROLD" in aging brain.
复制标题
不对称的连通性降低及其与大脑衰老的“哈罗德”的关系。
DOI：
10.1016/j.brainres.2009.08.004
复制
发表时间：
2009-10-27
期刊：
影响因子：
2.9
通讯作者：
Hu, Xiaoping
中科院分区：
文献类型：
--
作者：
Li, Zhihao;Moore, Anna Bacon;Tyner, Callie;Hu, Xiaoping
关键词：
老年人半球不对称性减少（HAROLD）在功能性脑老化研究中经常被报道。它通常被认为是一种可塑性大脑重组，为单侧神经效率下降提供补偿。然而，可塑性功能改变也可能与神经连接的变化有关。使用激活和静息状态的功能磁共振成像（fMRI）以及扩散张量成像（DTI），我们检查是否功能和结构连接有关的前额叶工作记忆功能是不对称的减少在两个半球的老龄化的大脑;如果是的话，这些不对称的连接下降是否与不对称减少功能激活。通过言语工作记忆激活定义的感兴趣区域，揭示了虽然神经连接在衰老大脑中普遍减少，但前额叶-顶叶静息功能连接在左半球得到更好的保留，而前额叶DTI纤维通路在右半球得到更好的保留。此外，功能激活的偏侧化变化与静息连接的偏侧化变化呈负相关，与结构连接的偏侧化变化呈正相关。这些结果揭示了衰老的神经元改变的其他方面，并表明不对称连接减少和HAROLD之间的联系。
Hemispheric asymmetry reduction in older adults (HAROLD) has been frequently reported in studies of functional brain aging. It is commonly considered to be a plastic brain reorganization that provides compensation for declining unilateral neural efficiency. However, plastic functional alterations may also be associated with neural connectivity changes. Using activation and resting state functional magnetic resonance imaging (fMRI) as well as diffusion tensor imaging (DTI), we examined whether functional and structural connectivity related to prefrontal working memory function is asymmetrically reduced in the two hemispheres of the aging brain; and if yes, whether these asymmetric connectivity declines are correlated with asymmetry reduction in functional activation. With regions of interests defined by verbal working memory activations, it is revealed that although neural connectivity is generally reduced in the aging brain, prefrontal-parietal resting functional connectivity is better preserved in the left hemisphere while prefrontal DTI fiber pathways are better preserved in the right hemisphere. In addition, the laterality change of the functional activation is negatively correlated with that of the resting connectivity and positively correlated with that of the structural connectivity. These results reveal additional aspects of the neuronal alterations of aging and suggest a link between asymmetric connectivity reduction and HAROLD.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
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影响因子：
3.7
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DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
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影响因子：
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DOI：
10.1073/pnas.0601417103
发表时间：
2006-09-12
影响因子：
11.1
作者：
Damoiseaux, J. S.;Rombouts, S. A. R. B.;Beckmann, C. F.
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Beckmann, C. F.