Understanding and Harnessing Epithelial‒Mesenchymal Interactions in the Development of Palmoplantar Identity.

Understanding and Harnessing Epithelial‒Mesenchymal Interactions in the Development of Palmoplantar Identity.
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DOI:
10.1016/j.jid.2021.06.016
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发表时间:
2022-03
期刊:
The Journal of investigative dermatology
影响因子:
--
通讯作者:
Garza LA
Garza LA
中科院分区:
其他
文献类型:
--
作者:
Tsai J;Rostom M;Garza LA

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掌跖皮肤有几个独特的特点,如增加厚度,高弹性,色素减退,毛囊缺乏。掌跖同一性的建立是通过角质形成细胞-成纤维细胞相互作用发生的,其中角蛋白9表达和Wnt信号传导起关键作用。了解掌跖特征是如何发育的,可能有助于在掌跖和非掌跖身体部位复制它们。
Palmoplantar skin has several unique characteristics such as increased thickness, high resilience, hypopigmentation, and lack of hair follicles. The establishment of palmoplantar identity occurs through keratinocyte-fibroblast interactions, with keratin 9 expression and Wnt signaling playing key roles. Understanding how palmoplantar features develop may help efforts to reproduce them at both palmoplantar and non-palmoplantar body sites.
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