High expression of phosphorylated focal adhesion kinase predicts a poor prognosis in human colorectal cancer.
High expression of phosphorylated focal adhesion kinase predicts a poor prognosis in human colorectal cancer.
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DOI：
10.3389/fphar.2022.989999
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发表时间：
2022
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
背景：磷酸化粘着斑激酶（FAK）与多种恶性肿瘤密切相关。p-FAK在结直肠癌（CRC）中的作用仍存在争议。本研究旨在探讨p-FAK在结直肠癌预后中的作用。 研究方法：采用免疫组化方法对908例结直肠癌患者的癌组织、癌旁组织、正常组织、腺瘤和转移组织中p-FAK表达的临床意义进行了评价。在肿瘤和其他组织中研究p-FAK表达与CRC发生的相关性。采用Kaplan-Meier生存分析和考克斯回归模型分析影响预后的因素。 结果：p-FAK在结直肠癌及转移癌组织中明显过表达。与p-FAK低表达患者相比，p-FAK高表达患者的总生存期[风险比（HR），2.200; 95%可信区间（CI），1.265-3.452; p < 0.01]和无病生存期较短。校正其他预后因素后，多变量考克斯分析显示，HR为2.004，95% CI为1.262-3.382，p < 0.01。p-FAK的高表达也与接受辅助化疗的患者化疗反应较差有关（p < 0.01）。 结论：p-FAK表达水平是大肠癌的独立危险因素，可作为大肠癌预后的生物学指标。p-FAK高表达预示着CRC预后不良以及化疗反应差。
Background: Phosphorylated Focal adhesion kinase (FAK) has been reported to be intimately involved in various malignant tumors. The effect of p-FAK on colorectal cancer (CRC) is still disputable. The purpose of this study is to investigate the role of p-FAK in the prognosis of colorectal cancer. Methods: The clinical significance of p-FAK expression in CRC was evaluated by immunohistochemistry in a large cohort, including carcinoma and para-carcinoma tissues from 908 patients, and normal tissues, adenoma, and metastasis tissues. The correlation between p-FAK expression and CRC occurrence was investigated in tumor and other tissues. Factors contributing to prognosis were evaluated using Kaplan-Meier survival analysis and Cox regression model. Results: p-FAK is apparently overexpressed in CRC and metastasis tissues. Compared with low p-FAK expression, patients with high p-FAK expression had shorter overall survival [hazard ratio (HR), 2.200; 95% confidence interval (CI), 1.265–3.452; p < 0.01] and disease-free survival (HR, 2.004; 95% CI 1.262–3.382; p < 0.01) in multivariate Cox analysis after adjusting other prognostic factors. High p-FAK expression was also related to a worse chemotherapeutic response in patients who achieved adjuvant chemotherapy (p < 0.01). Conclusion: Expression level of p-FAK is an independent risk factor and can serve as a prognostic biomarker for CRC. High p-FAK expression predicts an unfavorable prognosis of CRC as well as poor chemotherapeutic response.
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影响因子：
6.2
作者：
Tiede S;Meyer-Schaller N;Kalathur RKR;Ivanek R;Fagiani E;Schmassmann P;Stillhard P;Häfliger S;Kraut N;Schweifer N;Waizenegger IC;Bill R;Christofori G
通讯作者：
Christofori G
影响因子：
--
作者：
Huang, Kun;Gao, Ningning;Wang, Xuemei
通讯作者：
Wang, Xuemei
影响因子：
6.1
作者：
Xia C;Dong X;Li H;Cao M;Sun D;He S;Yang F;Yan X;Zhang S;Li N;Chen W
通讯作者：
Chen W
影响因子：
11.5
作者：
Lee, Mei-Yi;Chou, Cheng-Yang;Shen, Meng-Ru
通讯作者：
Shen, Meng-Ru
影响因子：
6.4
作者：
Yu, Hong-Gang;Tong, Shi-Lun;Yu, Jie-Ping
通讯作者：
Yu, Jie-Ping