Correlates of hippocampal complex-spike cell activity in rats performing a nonspatial radial maze task
Correlates of hippocampal complex-spike cell activity in rats performing a nonspatial radial maze task
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执行非空间径向迷宫任务的大鼠海马复合体尖峰细胞活性的相关性
DOI：
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发表时间：
1994
影响因子：
5.3
通讯作者：
H. Eichenbaum
中科院分区：
文献类型：
--
作者：
B. Young;G. D. Fox;H. Eichenbaum
对海马体位置细胞的观察形成了支持海马体致力于空间处理这一观点的主要证据。然而，大多数证明海马体单元活动的空间特性的研究都采用了强调空间线索而最小化非空间线索的任务。在本实验中，我们记录了执行非空间径向迷宫任务的大鼠海马复合体-刺突细胞的活动。该任务的表现由迷宫臂上的局部视觉触觉线索引导，而远端空间线索被最小化并变得无关紧要。研究了三个变量对单位活动的影响：手臂上的线索类型、手臂的空间位置和动物在手臂上的相对位置。在记录的单位中，近五分之一被归类为“线索细胞”，因为它们的活动与线索类型有关，而与空间位置无关。相反，相似比例的单元被归类为“位置细胞”，因为它们的活动与位置有关，而与线索类型无关。在另外相似比例的单位中，射击只受相对位置的影响，而不受局部线索或空间位置的影响。然而，对于大多数单元，放电与这三个变量的组合有关，这表明大多数海马神经元编码空间和局部线索信息之间的连接或关系。这种模式的结果表明，当局部而非远端空间线索被强调时，海马神经活动受到显著的非空间线索的强烈影响，并没有显示出位置编码的压倒性优势。这些发现与海马体选择性参与空间处理的假设不一致，相反，支持海马体在重要实验变量之间编码空间和非空间关系的更广泛观点。
The observation of hippocampal place cells forms a major line of evidence supporting the view that the hippocampus is dedicated to spatial processing. However, most studies demonstrating the spatial properties of hippocampal unit activity have employed tasks that emphasize spatial cues but minimize nonspatial cues. In the present experiment we recorded the activity of hippocampal complex-spike cells from rats performing a nonspatial radial maze task. Performance in this task was guided by local visual-tactile cues on the maze arms, while distal spatial cues were minimized and made irrelevant. The influence of three variables on unit activity was examined:type of cue on an arm, spatial location of an arm, and the relative position of the animal on an arm. Of the units recorded, almost one-fifth were classified as “cue cells” in that their activity was associated with cue type but not spatial location. Conversely, a similar proportion of the units were classified as “place cells” in that their activity was associated with location, but not cue type. In an additional similar proportion of units, firing was influenced only by relative position and not by local cues or spatial locations. For the majority of units, however, firing was related to combinations of these three variables, indicating that most hippocampal neurons encoded conjunctions or relations between spatial and local cue information. This pattern of results indicates that when local rather than distal spatial cues are emphasized, hippocampal neural activity is strongly influenced by salient nonspatial cues and shows no overwhelming predominance of place coding. These findings are at odds with the hypothesis that the hippocampus is selectively involved in spatial processing and, conversely, support the broader view that the hippocampus encodes both spatial and nonspatial relations among important experimental variables.
海马细胞放电与大鼠的延迟匹配样本表现相关。
影响因子：
1.9
作者：
Hampson,RE;Heyser,CJ;Deadwyler,SA
通讯作者：
Deadwyler,SA
影响因子：
2.5
作者：
E. Christian;S. Deadwyler
通讯作者：
E. Christian;S. Deadwyler