Subregional Structural Alterations in Hippocampus and Nucleus Accumbens Correlate with the Clinical Impairment in Patients with Alzheimer's Disease Clinical Spectrum: Parallel Combining Volume and Vertex-Based Approach.
Subregional Structural Alterations in Hippocampus and Nucleus Accumbens Correlate with the Clinical Impairment in Patients with Alzheimer's Disease Clinical Spectrum: Parallel Combining Volume and Vertex-Based Approach.
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DOI：
10.3389/fneur.2017.00399
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发表时间：
2017
影响因子：
3.4
通讯作者：
Zhang B
中科院分区：
文献类型：
--
作者：
Nie X;Sun Y;Wan S;Zhao H;Liu R;Li X;Wu S;Nedelska Z;Hort J;Qing Z;Xu Y;Zhang B
深层灰质结构与记忆和其他重要功能有关，这些功能在阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 中受损。然而，AD 和 MCI 中这些结构的次区域萎缩和变形的系统表征仍需要更多研究。在本文中，我们结合复杂的体积分析和基于顶点的分析，研究与正常对照（NC，n = 30）相比，AD（n = 30）和MCI患者（n = 30）的深部灰质结构的次区域结构改变模式及其与总体临床评分的关联。在所有七对结构中，与 NC 相比，AD 中的双侧海马和伏核均显示出显着萎缩（p<0.05）。但只有左侧海马背内侧、右侧海马腹侧、左侧伏隔核、右侧伏隔核后部的亚区域萎缩与较差的MMSE和MOCA临床评分相关（p<<0.05）。此外，右侧丘脑的内侧腹侧部分显着缩小，并且与临床评分相关，但其整体体积并未减少（p > 0.05）。总之，双侧海马和伏核这四个亚区的萎缩与患者认知功能障碍相关，可能是AD治疗的潜在靶区。表面分析可以为体积比较提供额外的信息，以发现深层灰质结构的早期病理进展。
Deep gray matter structures are associated with memory and other important functions that are impaired in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). However, systematic characterization of the subregional atrophy and deformations in these structures in AD and MCI still need more investigations. In this article, we combined complex volumetry- and vertex-based analysis to investigate the pattern of subregional structural alterations in deep gray matter structures and its association with global clinical scores in AD (n = 30) and MCI patients (n = 30), compared to normal controls (NCs, n = 30). Among all seven pairs of structures, the bilateral hippocampi and nucleus accumbens showed significant atrophy in AD compared with NCs (p < 0.05). But only the subregional atrophy in the dorsal–medial part of the left hippocampus, the ventral part of right hippocampus, and the left nucleus accumbens, the posterior part of the right nucleus accumbens correlated with the worse clinical scores of MMSE and MOCA (p < 0.05). Furthermore, the medial–ventral part of right thalamus significantly shrank and correlated with clinical scores without decreasing in its whole volume (p > 0.05). In conclusion, the atrophy of these four subregions in bilateral hippocampi and nucleus accumbens was associated with cognitive impairment of patients, which might be potential target regions of treatment in AD. The surface analysis could provide additional information to volume comparison in finding the early pathological progress in deep gray matter structures.
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