tRNA gene identity affects nuclear positioning.
tRNA gene identity affects nuclear positioning.
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DOI：
10.1371/journal.pone.0029267
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
O'Sullivan JM
中科院分区：
文献类型：
--
作者：
Rodley CD;Pai DA;Mills TA;Engelke DR;O'Sullivan JM
The three-dimensional organization of genomes is dynamic and plays a critical role in the regulation of cellular development and phenotypes. Here we use proximity-based ligation methods (i.e. chromosome conformation capture [3C] and circularized chromosome confrmation capture [4C]) to explore the spatial organization of tRNA genes and their locus-specific interactions with the ribosomal DNA. Directed replacement of one lysine and two leucine tRNA loci shows that tRNA spatial organization depends on both tRNA coding sequence identity and the surrounding chromosomal loci. These observations support a model whereby the three-dimensional, spatial organization of tRNA loci within the nucleus utilizes tRNA gene-specific signals to affect local interactions, though broader organization of chromosomal regions are determined by factors outside the tRNA genes themselves.
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影响因子：
7.5
作者：
Cremer, Thomas;Cremer, Marion;Fakan, Stanislav
通讯作者：
Fakan, Stanislav
影响因子：
56.9
作者：
Thompson, M;Haeusler, RA;Engelke, DR
通讯作者：
Engelke, DR
影响因子：
10.5
作者：
D'Ambrosio, Claudio;Schmidt, Christine Katrin;Uhlmann, Frank
通讯作者：
Uhlmann, Frank
影响因子：
9.2
作者：
Machín, F;Paschos, K;Aragón, L
通讯作者：
Aragón, L
DOI：
10.1083/jcb.149.4.811
发表时间：
2000-05-15
期刊：
The Journal of cell biology
影响因子：
--
作者：
Freeman L;Aragon-Alcaide L;Strunnikov A
通讯作者：
Strunnikov A