Vanilloid-induced conduction analgesia: selective, dose-dependent, long-lasting, with a low level of potential neurotoxicity.
Vanilloid-induced conduction analgesia: selective, dose-dependent, long-lasting, with a low level of potential neurotoxicity.
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DOI：
10.1213/ane.0b013e318162cfa3
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发表时间：
2008-07
影响因子：
5.7
通讯作者：
Kissin I
中科院分区：
文献类型：
--
作者：
Kissin I
应用于周围神经的香草受体激动剂（辣椒素，树脂干扰素，[RTX]）提供传导阻断。与局部麻醉药产生的传导麻醉镇痛成分相反，香草受体激动剂提供的传导镇痛与抑制与疼痛无关的运动或感觉功能无关。香草受体激动剂选择性地提供传导镇痛，因为它们对神经干的作用仅限于C-和a -纤维。RTX比辣椒素更有效，有更宽的治疗窗口。在大鼠实验中，神经周围RTX产生了持久的热感和机械性痛觉减退，有效浓度（从0.00003%到0.001%）相差很大，效果持续数小时至数周。在切口疼痛模型中，RTX神经阻滞可阻止热、机械痛觉过敏以及疼痛行为的发展。rtx诱导的传导阻断有TRPV1激动剂固有的缺点——初始兴奋（疼痛）；因此，应该注射局部麻醉剂来预防它。当RTX以提供传导镇痛所需的剂量作用于大鼠坐骨神经时，无髓鞘纤维变性的频率比利多卡因治疗浓度低一个数量级以上。这些有希望的结果应该在啮齿类动物（猪、羊）以外的物种中进行实验来证实。综上所述，这些数据表明香草素诱导的传导镇痛可能具有临床适用性。
Vanilloid agonists (capsaicin, resiniferatoxin, [RTX]) applied to the peripheral nerves provide conduction blockade. In contrast to the analgesic component of conduction anesthesia produced by local anesthetics, vanilloid agonists provide conduction analgesia not associated with suppression of motor or sensory functions not related to pain. Vanilloid agonists provide conduction analgesia selectively because their effect on the nerve trunks is limited to C- and Aδ-fibers. RTX is much more potent than capsaicin and has a wider therapeutic window. In the rat experiments perineural RTX produced a long-lasting thermal and mechanical hypoalgesia with a very wide separation between effective concentrations [from 0.00003% to 0.001%] providing the effect lasting from several hours to several weeks. A nerve block with RTX prevented the development of thermal and mechanical hyperalgesia as well as pain behavior in a model of incisional pain. RTX-induced conduction blockade has an inherent drawback of TRPV1 agonists – the initial excitation (pain); therefore, a local anesthetic should be injected to prevent it. When RTX was applied to the rat’s sciatic nerve in doses necessary to provide conduction analgesia, the frequency of unmyelinated fiber degeneration was more than an order of magnitude lower than that with the therapeutic concentration of lidocaine. These promising results should be confirmed by experiments in species other than rodents (pigs, sheep). Taken together, the data indicate possible clinical applicability of vanilloid-induced conduction analgesia.
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影响因子：
2.5
作者：
Grosskreutz, J;Quasthoff, S;Grafe, P
通讯作者：
Grafe, P
影响因子：
3.4
作者：
Guo, A;Vulchanova, L;Elde, R
通讯作者：
Elde, R
DOI：
10.1001/archneurpsyc.1933.02240100090008
发表时间：
1933-04-01
影响因子：
--
作者：
Heinbecker, P;Bishop, GH;O'Leary, J
通讯作者：
O'Leary, J
影响因子：
168.9
作者：
Cruz, F;Guimaraes, M;Reis, M
通讯作者：
Reis, M
影响因子：
7.4
作者：
AINSWORTH, A;HALL, P;POLAK, JM
通讯作者：
POLAK, JM