Discovering environmental management opportunities for infectious disease control.
Discovering environmental management opportunities for infectious disease control.
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DOI：
10.1038/s41598-021-85250-1
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发表时间：
2021-03-19
影响因子：
4.6
通讯作者：
Wagener T
中科院分区：
文献类型：
--
作者：
Beltrame L;Rose Vineer H;Walker JG;Morgan ER;Vickerman P;Wagener T
气候变化和新出现的耐药性使许多传染病的控制越来越具有挑战性，并减少了对药物治疗作为唯一解决问题办法的完全依赖。由于疾病传播往往取决于可以改变的环境条件，如果我们能够在政策相关的规模上评估其潜在效益，这种改变可能对减少风险至关重要。然而，迄今为止，环境管理为此目的的价值很少受到关注。在这里，以英国家畜肝片形吸虫病的寄生虫病为例，我们展示了如何应用机械水文流行病学模型来了解疾病风险驱动因素和环境管理在一个大型异质领域的有效性。我们的研究结果表明，天气和其他环境特征如何相互作用，以确定疾病的传播潜力，并揭示了环境干预措施，如风险规避管理策略，可以提供一个有价值的替代或补充，以目前的治疗为基础的控制实践。
Climate change and emerging drug resistance make the control of many infectious diseases increasingly challenging and diminish the exclusive reliance on drug treatment as sole solution to the problem. As disease transmission often depends on environmental conditions that can be modified, such modifications may become crucial to risk reduction if we can assess their potential benefit at policy-relevant scales. However, so far, the value of environmental management for this purpose has received little attention. Here, using the parasitic disease of fasciolosis in livestock in the UK as a case study, we demonstrate how mechanistic hydro-epidemiological modelling can be applied to understand disease risk drivers and the efficacy of environmental management across a large heterogeneous domain. Our results show how weather and other environmental characteristics interact to define disease transmission potential and reveal that environmental interventions such as risk avoidance management strategies can provide a valuable alternative or complement to current treatment-based control practice.
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影响因子：
5.4
作者：
Bertuzzo, E.;Azaele, S.;Rinaldo, A.
通讯作者：
Rinaldo, A.
影响因子：
4.9
作者：
Mahmoud, Mohammed;Liu, Yuqiong;Winter, Larry
通讯作者：
Winter, Larry
影响因子：
10.4
作者：
Eisenberg, Joseph N. S.;Desai, Manish A.;Scott, James C.
通讯作者：
Scott, James C.
DOI：
10.1098/rsif.2018.0072
发表时间：
2018-08
期刊：
Journal of the Royal Society, Interface
影响因子：
--
作者：
Beltrame L;Dunne T;Vineer HR;Walker JG;Morgan ER;Vickerman P;McCann CM;Williams DJL;Wagener T
通讯作者：
Wagener T
影响因子：
3.8
作者：
Lo Iacono G;Armstrong B;Fleming LE;Elson R;Kovats S;Vardoulakis S;Nichols GL
通讯作者：
Nichols GL