Potential conservation of circadian clock proteins in the phylum Nematoda as revealed by bioinformatic searches.
Potential conservation of circadian clock proteins in the phylum Nematoda as revealed by bioinformatic searches.
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DOI：
10.1371/journal.pone.0112871
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Golombek DA
中科院分区：
文献类型：
--
作者：
Romanowski A;Garavaglia MJ;Goya ME;Ghiringhelli PD;Golombek DA
尽管C. elegans，它的分子钟仍然难以捉摸。在这项工作中，我们采用了一种新的生物信息学方法，应用概率方法，在C.线虫和线虫门的其他成员。通过这种方法，我们发现线虫含有与昆虫和哺乳动物时钟的核心和辅助蛋白最相关的蛋白质，这为线虫时钟和昼夜节律系统的进化提供了新的见解。
Although several circadian rhythms have been described in C. elegans, its molecular clock remains elusive. In this work we employed a novel bioinformatic approach, applying probabilistic methodologies, to search for circadian clock proteins of several of the best studied circadian model organisms of different taxa (Mus musculus, Drosophila melanogaster, Neurospora crassa, Arabidopsis thaliana and Synechoccocus elongatus) in the proteomes of C. elegans and other members of the phylum Nematoda. With this approach we found that the Nematoda contain proteins most related to the core and accessory proteins of the insect and mammalian clocks, which provide new insights into the nematode clock and the evolution of the circadian system.
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