Urinary epidermal growth factor levels correlate with cardiovascular autonomic neuropathy indices in adults with type 1 diabetes.
Urinary epidermal growth factor levels correlate with cardiovascular autonomic neuropathy indices in adults with type 1 diabetes.
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DOI：
10.1111/jdi.14049
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发表时间：
2023-10
影响因子：
3.2
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究旨在探讨尿内皮生长因子（uEGF）与成人1型糖尿病患者心血管自主神经病变（CAN）的关系。在基线时收集1型糖尿病成人的uEGF水平和标准化CAN测量值，并每年收集一次，持续3年。采用线性回归分析和线性混合效应模型进行分析。该队列中（n = 44，59%为女性，平均±标准差年龄34 ± 13岁，糖尿病病程14 ± 6年），较低的基线uEGF水平与较低的基线呼气：吸气比相关（P = 0.03）和Valsalva比率的年度下降幅度更大（P = 0.02），并与较低的低频功率：高频功率比相关（P = 0.01）和调整年龄、性别、体重指数和血红蛋白A1C后低频功率：高频功率比的年度变化更大（P = 0.01）。总之，基线uEGF水平与CAN指数的基线和纵向变化相关。需要一项大规模的长期研究来验证uEGF作为可靠的CAN生物标志物。观察基线尿内皮生长因子与基线和心血管自主神经病变指数纵向变化之间的关系。需要进行一项大规模的长期研究，以评估尿内皮生长因子是否可以作为心血管自主神经病变的可靠非侵入性生物标志物。
The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was evaluated. uEGF levels at baseline and standardized CAN measures were collected at baseline and annually for 3 years for type 1 diabetes adults. Linear regression analysis and linear mixed effects model were used for analysis. In this cohort (n = 44, 59% women, mean ± standard deviation age 34 ± 13 years and diabetes duration 14 ± 6 years), lower baseline uEGF levels correlated with lower baseline expiration : inspiration ratios (P = 0.03) and greater annual declines in Valsalva ratios (P = 0.02) in the unadjusted model, and correlated with lower low‐frequency power : high‐frequency power ratios (P = 0.01) and greater annual changes in low‐frequency power : high‐frequency power ratios (P = 0.01) after adjustment for age, sex, body mass index, and hemoglobin A1C. In conclusion, baseline uEGF levels correlate to baseline and longitudinal changes in CAN indices. A large‐scale, long‐term study is needed to validate uEGF as a reliable CAN biomarker. Relationships between baseline urinary endothelial growth factor and baseline and longitudinal changes in cardiovascular autonomic neuropathy indices were observed. A large‐scale, long‐term study is needed to evaluate if urinary endothelial growth factor can serve as a reliable non‐invasive biomarker of cardiovascular autonomic neuropathy.
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影响因子：
1.6
作者：
Arnold R;Issar T;Krishnan AV;Pussell BA
通讯作者：
Pussell BA
影响因子：
7.7
作者：
Mathew, Anna, V;Jaiswal, Mamta;Pop-Busui, Rodica
通讯作者：
Pop-Busui, Rodica
DOI：
10.2215/cjn.11441114
发表时间：
2015-07-01
影响因子：
9.8
作者：
Orlov, Steven;Cherney, David Z. I.;Perkins, Bruce A.
通讯作者：
Perkins, Bruce A.
影响因子：
5.1
作者：
Ledeganck, Kristien J.;den Brinker, Marieke;Trouet, Dominique
通讯作者：
Trouet, Dominique
影响因子：
3
作者：
Wheelock, Kevin M.;Jaiswal, Mamta;Pop-Busui, Rodica
通讯作者：
Pop-Busui, Rodica