Phospholipid Remodeling in Physiology and Disease.
Phospholipid Remodeling in Physiology and Disease.
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DOI：
10.1146/annurev-physiol-020518-114444
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发表时间：
2019-02-10
影响因子：
18.2
通讯作者：
Tontonoz P
中科院分区：
文献类型：
--
作者：
Wang B;Tontonoz P
磷脂是生物膜的主要成分。磷脂的脂肪酰链组成决定了膜的生物物理性质，从而影响其对生物过程的影响。脂肪酰链的组成也通过称为兰兹循环的脱酰化和反应途径进行积极的调节。最近对小鼠遗传模型的研究表明，溶血磷脂酰基转移酶(LPCAT)催化脂肪酰链进入磷脂酰胆碱的sn-2位点，在病理生理学中发挥重要作用。LPCAT家族的两个成员LPCAT1和LPCAT3已经得到了特别好的研究。由于LPCAT1在肺表面活性物质生物合成中的作用，LPCAT1对正常的肺功能至关重要。LPCAT3通过调节肠道脂肪吸收、脂蛋白分泌和肝脏新生脂肪生成来维持全身脂质平衡。越来越多的证据还表明，LPCAT活性的变化可能与病理情况有关，包括非酒精性脂肪性肝病、动脉粥样硬化、病毒感染和癌症。对LPCAT活性和膜磷脂成分的药理学操作可能为这些疾病提供新的治疗选择。
Phospholipids are major constituents of biological membranes. The fatty acyl chain composition of phospholipids determines the biophysical properties of membranes and thereby affects their impact on biological processes. The composition of fatty acyl chains is also actively regulated through a deacylation and reacylation pathway called Lands’ cycle. Recent studies of mouse genetic models have demonstrated that lysophosphatidylcholine acyltransferases (LPCATs), which catalyze the incorporation of fatty acyl chains into the sn-2 site of phosphatidylcholine, play important roles in pathophysiology. Two LPCAT family members, LPCAT1 and LPCAT3, have been particularly well studied. LPCAT1 is crucial for proper lung function due to its role in pulmonary surfactant biosynthesis. LPCAT3 maintains systemic lipid homeostasis by regulating lipid absorption in intestine, lipoprotein secretion, and de novo lipogenesis in liver. Mounting evidence also suggests that changes in LPCAT activity may be potentially involved in pathological conditions, including nonalcoholic fatty liver disease, atherosclerosis, viral infections, and cancer. Pharmacological manipulation of LPCAT activity and membrane phospholipid composition may provide new therapeutic options for these conditions.
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影响因子：
4.6
作者：
Dashti, Monireh;Kulik, Willem;Hoek, Frans;Veerman, Enno C.;Peppelenbosch, Maikel P.;Rezaee, Farhad
通讯作者：
Rezaee, Farhad
DOI：
10.1073/pnas.0604946103
发表时间：
2006-08-01
影响因子：
11.1
作者：
Chen, Xueni;Hyatt, Brian A.;Shannon, John M.
通讯作者：
Shannon, John M.
影响因子：
29.4
作者：
Camilleri M
通讯作者：
Camilleri M
DOI：
10.1165/rcmb.2006-0037oc
发表时间：
2006-08-01
影响因子：
6.4
作者：
Chang, Yongsheng;Edeen, Karen;Mason, Robert J.
通讯作者：
Mason, Robert J.
溶血磷脂酰胆碱酰基转移酶2介导的脂质液滴生产支持结直肠癌的化学耐药性。
影响因子：
16.6
作者：
Cotte AK;Aires V;Fredon M;Limagne E;Derangère V;Thibaudin M;Humblin E;Scagliarini A;de Barros JP;Hillon P;Ghiringhelli F;Delmas D
通讯作者：
Delmas D