Decline in ventricular function as a result of general anesthesia in pediatric heart transplant recipients.
Decline in ventricular function as a result of general anesthesia in pediatric heart transplant recipients.
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DOI：
10.1111/petr.12825
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发表时间：
2016-12
影响因子：
1.3
通讯作者：
Butts RJ
中科院分区：
文献类型：
--
作者：
Elhoff JJ;Chowdhury SM;Taylor CL;Hassid M;Savage AJ;Atz AM;Butts RJ
超声心动图经常在麻醉下进行，例如在儿童HTX接受者使用EMB进行心导管插入术时。麻醉剂可能会抑制心脏功能，从而引起排斥反应。这项研究的目的是比较17名接受HTX治疗的儿童在GA前和GA期间的超声心动图测量的心功能。GA组几乎所有的心脏收缩功能指标均显著降低，包括EF(−4.2%±1.2，P<0.01)和RV FAC(−0.05±0.02，P=0.04)。移植后第1年(n=9)的EF较移植后第1年(n=8；−6.0%±1.2vs2.1vs2.1vs2.1vs2.1±2.0vs2.1vs2.1vs2.1vs2.1vs2.1vs2.1vs2.1vs2.1vs2.1vs2.1vs2.1vs2.1vs2.1vs2.1vs2.1vs2.1vs2.1vs2.1vs2.1vs2.1±2.0EF值有更显著的下降趋势。这一信息量化了在GA下接受HTX的儿科患者应该预期的双室功能下降的程度，并可以帮助移植临床医生避免不必要的治疗GA引起的一过性心功能障碍。
Echocardiography is frequently performed under anesthesia during procedures such as cardiac catheterization with EMB in pediatric HTx recipients. Anesthetic agents may depress ventricular function, resulting in concern for rejection. The aim of this study was to compare ventricular function as measured by echocardiography before and during GA in 17 pediatric HTx recipients. Nearly all markers of ventricular systolic function were significantly decreased under GA, including EF (−4.2% ±1.2, P < .01) and RV FAC (−0.05 ± 0.02, P = .04). Subjects in the first post-transplant year (n = 9) trended toward a more significant decrease in EF vs those beyond the first post-transplant year (n = 8; −6.0% ±1.2 vs −2.1 ± 2.0, P = .1). This information quantifies a decline in biventricular function that should be expected in pediatric HTx recipients while under GA and can assist the transplant clinician in avoiding unnecessary treatment of transient GA-induced ventricular dysfunction.
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DOI：
10.1016/j.echo.2015.11.016
发表时间：
2016-03
期刊：
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
影响因子：
--
作者：
Levy PT;Machefsky A;Sanchez AA;Patel MD;Rogal S;Fowler S;Yaeger L;Hardi A;Holland MR;Hamvas A;Singh GK
通讯作者：
Singh GK
影响因子：
7.5
作者：
Lunze, Fatima I.;Colan, Steven D.;Singh, Tajinder P.
通讯作者：
Singh, Tajinder P.
DOI：
10.1016/0888-6296(88)90264-5
发表时间：
1988-04-01
期刊：
Journal of cardiothoracic anesthesia
影响因子：
--
作者：
Glenski, J A;Friesen, R H;Henry, D B
通讯作者：
Henry, D B
影响因子：
1.6
作者：
Kailin, Joshua A.;Miyamoto, Shelley D.;Landeck, Bruce F.
通讯作者：
Landeck, Bruce F.
影响因子：
8.8
作者：
Rivenes, SM;Lewin, MB;Andropoulos, DB
通讯作者：
Andropoulos, DB