Chaperoning histones during DNA replication and repair.

Chaperoning histones during DNA replication and repair.
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DOI:
10.1016/j.cell.2010.01.004
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发表时间:
2010-01-22
期刊:
影响因子:
64.5
通讯作者:
Tyler JK
Tyler JK
中科院分区:
生物学1区
文献类型:
--
作者:
Ransom M;Dennehey BK;Tyler JK

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核DNA紧密包装在染色质中,这深刻地影响DNA复制、转录、修复和重组。碱性组蛋白和酸性DNA之间广泛的相互作用使染色质的核小体单位成为一个高度稳定的实体。为了让细胞机器接近DNA,染色质必须被解开,DNA中的组蛋白必须被清除。相反,DNA必须重新包装成染色质。本文综述了组蛋白伴侣在DNA复制和修复过程中对染色质组装和拆卸的作用。
Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA replication, transcription, repair, and recombination. The extensive interactions between the basic histones proteins and acidic DNA make the nucleosomal unit of chromatin a highly stable entity. For the cellular machinery to access the DNA, the chromatin must be unwound and the DNA cleared of histone proteins. Conversely, the DNA has to be repackaged into chromatin afterwards. This review focuses on the roles of the histone chaperones in assembling and disassembling chromatin during the processes of DNA replication and repair.
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