Chaperoning histones during DNA replication and repair.
Chaperoning histones during DNA replication and repair.
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DOI:
10.1016/j.cell.2010.01.004
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发表时间:
2010-01-22
期刊:
影响因子:
64.5
通讯作者:
Tyler JK
中科院分区:
文献类型:
--
作者:
Ransom M;Dennehey BK;Tyler JK
Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA replication, transcription, repair, and recombination. The extensive interactions between the basic histones proteins and acidic DNA make the nucleosomal unit of chromatin a highly stable entity. For the cellular machinery to access the DNA, the chromatin must be unwound and the DNA cleared of histone proteins. Conversely, the DNA has to be repackaged into chromatin afterwards. This review focuses on the roles of the histone chaperones in assembling and disassembling chromatin during the processes of DNA replication and repair.
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