Cytokines that promote nerve regeneration.
Cytokines that promote nerve regeneration.
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DOI：
10.1016/j.expneurol.2012.08.017
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发表时间：
2012-12
影响因子：
5.3
通讯作者：
Zigmond RE
中科院分区：
文献类型：
--
作者：
Zigmond RE
在轴突损伤后，再生在哺乳动物周围神经系统（PNS）中自发发生;然而，这在中枢神经系统（CNS）中极其罕见。神经再生通常被认为取决于两种类型的因素：内在和外在（Ferguson和Son，2011;博塞，2012）。限制CNS再生的外在因素的研究具有悠久的历史（Caroni和Schwab，1988; Galtrey和福塞特，2007; Lee和Zheng，2012）;然而，调节中枢神经元的内在生长能力的研究最近受到关注（Liu等人，2011年）。长期以来，人们一直认为部分内在机制涉及基因转录的变化，这是一系列变化中的一部分，被称为“细胞体反应”（沃森，1974; Grafstein，1975; Skene和Willard，1981 b; Smith和Skene，1997），并由轴突切断术诱导的因素或由其影响被轴突切断术消除的靶源性因素或两者触发（Cragg，1970; Zigmond，2012）在最近题为“IL-6 promotes regeneration and functional recovery after cortical spinal tract injury by reactivating intrinsic growth program of neurons and enhancing synapse formation”的论文中，Yang et al.（2012）报道了在背侧半切后将细胞因子白细胞介素（IL）-6输注到脊髓中促进了皮质脊髓束（CST）的再生和功能恢复，皮质脊髓束是一种被认为具有特别低的内在生长能力的神经通路（Liu等人，2010; Blackmore等人，2012年）。IL-6是称为糖蛋白（gp）130家族或IL-6家族的细胞因子家族的成员（Bazan，1991）。这些名称中的第一个来自于这样的事实，即这些细胞因子作用于一组异聚体受体，所有这些受体都含有信号亚基gp 130（Taga，1996）。gp 130的激活导致转录因子信号转导子和转录激活子3（STAT 3）被Janus激酶（JAK）磷酸化，
After axonal damage, regeneration occurs spontaneously in the mammalian peripheral nervous system (PNS); however, this is extremely rare in the central nervous system (CNS). Nerve regeneration is generally thought to depend on two types of factors: intrinsic and extrinsic (Ferguson and Son, 2011; Bosse, 2012). Study of the extrinsic factors that limit CNS regeneration has a long history (Caroni and Schwab, 1988; Galtrey and Fawcett, 2007; Lee and Zheng, 2012); however, study of what regulates the intrinsic growth capacity of central neurons has received attention much more recently (Liu et al., 2011). Part of the intrinsic mechanism has long been believed to involve changes in gene transcription, a part of a set of changes referred to as the “cell body response”(Watson, 1974; Grafstein, 1975; Skene and Willard, 1981b; Smith and Skene, 1997) and triggered either by factors induced by axotomy or by target derived factors whose influence is removed by axotomy or by both (Cragg, 1970; Zigmond, 2012).In a recent paper entitled “IL-6 promotes regeneration and functional recovery after cortical spinal tract injury by reactivating intrinsic growth program of neurons and enhancing synapse formation”, Yang et al.(2012) reported that infusion of the cytokine interleukin (IL)-6 into the spinal cord following a dorsal hemisection promoted regeneration and functional recovery of the corticospinal tract (CST), a nerve pathway considered to have a particularly low intrinsic growth capacity (Liu et al., 2010; Blackmore et al., 2012). IL-6 is a member of a family of cytokines referred to as the glycoprotein (gp) 130 family or the IL-6 family (Bazan, 1991). The first of these names comes from the fact that these cytokines act on a set of heteromeric receptors all of which contain the signaling subunit gp130 (Taga, 1996). Activation of gp130 leads to phosphorylation of the transcription factor signal transducer and activator of transcription 3 (STAT3) by the enzyme Janus kinase (JAK),
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DOI：
10.1073/pnas.91.15.7109
发表时间：
1994-07-19
影响因子：
11.1
作者：
BANNER, LR;PATTERSON, PH
通讯作者：
PATTERSON, PH
影响因子：
16.2
作者：
BAZAN, JF
通讯作者：
BAZAN, JF
影响因子：
16.2
作者：
Campbell, DS;Holt, CE
通讯作者：
Holt, CE
DOI：
10.1073/pnas.1119449109
发表时间：
2012-06-05
影响因子：
11.1
作者：
de Lima, Silmara;Koriyama, Yoshiki;Benowitz, Larry
通讯作者：
Benowitz, Larry
影响因子：
5.3
作者：
Christie, Kimberly J.;Webber, Christine A.;Zochodne, Douglas W.
通讯作者：
Zochodne, Douglas W.