Incidence Estimates of Acute Q Fever and Spotted Fever Group Rickettsioses, Kilimanjaro, Tanzania, from 2007 to 2008 and from 2012 to 2014.
Incidence Estimates of Acute Q Fever and Spotted Fever Group Rickettsioses, Kilimanjaro, Tanzania, from 2007 to 2008 and from 2012 to 2014.
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DOI：
10.4269/ajtmh.20-1036
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发表时间：
2021-12-20
期刊：
影响因子：
--
通讯作者：
Crump JA
中科院分区：
文献类型：
--
作者：
Pisharody S;Rubach MP;Carugati M;Nicholson WL;Perniciaro JL;Biggs HM;Maze MJ;Hertz JT;Halliday JEB;Allan KJ;Mmbaga BT;Saganda W;Lwezaula BF;Kazwala RR;Cleaveland S;Maro VP;Crump JA
Q热和斑点热群立克次体病（SFGR）是坦桑尼亚北方严重发热性疾病的常见原因。需要估计发病率以确定疾病负担的特征。使用混合监测，结合两个转诊医院的病例发现和医疗利用数据，我们估计了2007年至2008年和2012年至2014年坦桑尼亚基利曼哈罗莫希的急性Q热和SFGR的发病率。根据贝氏柯克斯体II期抗原（急性Q热）和康氏立克次体（2007-2008）或非洲立克次体（2012-2014）抗原（SFGR）的间接免疫荧光试验，病例定义为发热和急性和恢复期配对血清抗体滴度增加4倍或以上。卫生保健利用数据用于调整哨点监测的病例不确定性。2007年至2008年，在589名发热受试者中，344名受试者中有16名（4.7%）有Q热，307名受试者中有27名（8.8%）有SFGR。调整后的Q热和SFGR年发病率估计值分别为每10万人80例（不确定范围，20-454）和147例（不确定范围，52-645）。2012年至2014年，在1,114名发热受试者中，641名血清学配对的受试者中分别有52名（8.1%）和57名（8.9%）患有Q热和SFGR。调整后的Q热和SFGR年发病率估计值分别为每10万人56例（不确定范围，24-163）和75例（不确定范围，34-176）。我们发现大量的急性Q热和SFGR的发病率在坦桑尼亚北方在这两个研究期间。据我们所知，这些是撒哈拉以南非洲这两种疾病的首次发病率估计。我们的研究结果表明，这些感染的控制措施值得考虑。
Q fever and spotted fever group rickettsioses (SFGR) are common causes of severe febrile illness in northern Tanzania. Incidence estimates are needed to characterize the disease burden. Using hybrid surveillance—coupling case-finding at two referral hospitals and healthcare utilization data—we estimated the incidences of acute Q fever and SFGR in Moshi, Kilimanjaro, Tanzania, from 2007 to 2008 and from 2012 to 2014. Cases were defined as fever and a four-fold or greater increase in antibody titers of acute and convalescent paired sera according to the indirect immunofluorescence assay of Coxiella burnetii phase II antigen for acute Q fever and Rickettsia conorii (2007–2008) or Rickettsia africae (2012–2014) antigens for SFGR. Healthcare utilization data were used to adjust for underascertainment of cases by sentinel surveillance. For 2007 to 2008, among 589 febrile participants, 16 (4.7%) of 344 and 27 (8.8%) of 307 participants with paired serology had Q fever and SFGR, respectively. Adjusted annual incidence estimates of Q fever and SFGR were 80 (uncertainty range, 20–454) and 147 (uncertainty range, 52–645) per 100,000 persons, respectively. For 2012 to 2014, among 1,114 febrile participants, 52 (8.1%) and 57 (8.9%) of 641 participants with paired serology had Q fever and SFGR, respectively. Adjusted annual incidence estimates of Q fever and SFGR were 56 (uncertainty range, 24–163) and 75 (uncertainty range, 34–176) per 100,000 persons, respectively. We found substantial incidences of acute Q fever and SFGR in northern Tanzania during both study periods. To our knowledge, these are the first incidence estimates of either disease in sub-Saharan Africa. Our findings suggest that control measures for these infections warrant consideration.
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影响因子：
11.8
作者：
Langley G;Schaffner W;Farley MM;Lynfield R;Bennett NM;Reingold A;Thomas A;Harrison LH;Nichols M;Petit S;Miller L;Moore MR;Schrag SJ;Lessa FC;Skoff TH;MacNeil JR;Briere EC;Weston EJ;Van Beneden C
通讯作者：
Van Beneden C
使用基于医院的监测和坦桑尼亚的基于人群的医疗保健利用调查来估计钩端螺旋体病的发病率。
影响因子：
3.8
作者：
Biggs HM;Hertz JT;Munishi OM;Galloway RL;Marks F;Saganda W;Maro VP;Crump JA
通讯作者：
Crump JA
DOI：
10.1093/trstmh/try033
发表时间：
2018-03-01
影响因子：
2.2
作者：
Carugati M;Biggs HM;Maze MJ;Stoddard RA;Cash-Goldwasser S;Hertz JT;Halliday JEB;Saganda W;Lwezaula BF;Kazwala RR;Cleaveland S;Maro VP;Rubach MP;Crump JA
通讯作者：
Crump JA
DOI：
10.1128/cdli.9.2.324-328.2002
发表时间：
2002-03-01
期刊：
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
影响因子：
--
作者：
Fournier, PE;Jensenius, M;Raoult, D
通讯作者：
Raoult, D
影响因子：
6.4
作者：
de Sousa, Rita;Franca, Ana;Walker, David H.
通讯作者：
Walker, David H.