Incidence of human brucellosis in the Kilimanjaro Region of Tanzania in the periods 2007-2008 and 2012-2014.

Incidence of human brucellosis in the Kilimanjaro Region of Tanzania in the periods 2007-2008 and 2012-2014.
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DOI:
10.1093/trstmh/try033
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发表时间:
2018-03-01
影响因子:
2.2
通讯作者:
Crump JA
Crump JA
中科院分区:
医学4区
文献类型:
--
作者:
Carugati M;Biggs HM;Maze MJ;Stoddard RA;Cash-Goldwasser S;Hertz JT;Halliday JEB;Saganda W;Lwezaula BF;Kazwala RR;Cleaveland S;Maro VP;Rubach MP;Crump JA

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布鲁氏菌病导致人类及其牲畜大量发病。对撒哈拉以南非洲地区布鲁氏菌病发病率的可靠估计很少。利用通过哨点医院监测和医疗保健利用数据确定的病例,我们估计了 2007-2008 年和 2012-2014 年坦桑尼亚乞力马扎罗地区莫希城市和莫希农村地区的布鲁氏菌病发病率。病例是在两家哨点医院的发热患者中发现的,被定义为急性期和恢复期血清中布鲁氏菌镜下凝集试验滴度增加 4 倍,或者血培养布鲁氏菌属阳性。医疗保健利用调查的结果用于估计乘数,以考虑哨点医院未发现的病例。 2007 年至 2008 年期间登记的 585 名患者中,13 名 (2.2%) 患有布鲁氏菌病。在 2012 年至 2014 年期间登记的 1095 名患者中,32 名 (2.9%) 患有布鲁氏菌病。我们估计,2007-2008 年期间,布鲁氏菌病的发病率(范围基于敏感性分析)为每年每 10 万人 35 例(范围 32-93)例,2012-2014 年期间每年每 10 万人 33 例(范围 30-89)例。我们在坦桑尼亚北部发现了中等程度的布鲁氏菌病发病率,表明该疾病是该地区的地方病,是一个重要的人类健康问题。
Brucellosis causes substantial morbidity among humans and their livestock. There are few robust estimates of the incidence of brucellosis in sub-Saharan Africa. Using cases identified through sentinel hospital surveillance and health care utilization data, we estimated the incidence of brucellosis in Moshi Urban and Moshi Rural Districts, Kilimanjaro Region, Tanzania, for the periods 2007–2008 and 2012–2014. Cases were identified among febrile patients at two sentinel hospitals and were defined as having either a 4-fold increase in Brucella microscopic agglutination test titres between acute and convalescent serum or a blood culture positive for Brucella spp. Findings from a health care utilization survey were used to estimate multipliers to account for cases not seen at sentinel hospitals. Of 585 patients enrolled in the period 2007–2008, 13 (2.2%) had brucellosis. Among 1095 patients enrolled in the period 2012–2014, 32 (2.9%) had brucellosis. We estimated an incidence (range based on sensitivity analysis) of brucellosis of 35 (range 32–93) cases per 100 000 persons annually in the period 2007–2008 and 33 (range 30–89) cases per 100 000 persons annually in the period 2012–2014. We found a moderate incidence of brucellosis in northern Tanzania, suggesting that the disease is endemic and an important human health problem in this area.
使用基于医院的监测和坦桑尼亚的基于人群的医疗保健利用调查来估计钩端螺旋体病的发病率。
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