Dynamics of antibody response to BNT162b2 vaccine after six months: a longitudinal prospective study.
Dynamics of antibody response to BNT162b2 vaccine after six months: a longitudinal prospective study.
复制标题
DOI：
10.1016/j.lanepe.2021.100208
复制
发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Peterson P
中科院分区：
文献类型：
--
作者：
Naaber P;Tserel L;Kangro K;Sepp E;Jürjenson V;Adamson A;Haljasmägi L;Rumm AP;Maruste R;Kärner J;Gerhold JM;Planken A;Ustav M;Kisand K;Peterson P
SARS-CoV-2 mRNA疫苗已被证明具有很高的疗效，然而，关于免疫应答持续时间及其与年龄和副作用的关系的数据有限。我们研究了122名志愿者接种两剂BNT 162 b2疫苗后长达6个月的抗体和记忆T细胞反应，并将研究结果与年龄和副作用相关联。我们发现在第二次给药后对刺突蛋白的强烈抗体应答。然而，抗体水平在接种后12周和6个月下降，表明免疫应答随时间减弱。在第二剂接种后6个月，刺突抗体水平与接种一剂疫苗的人或COVID-19恢复期个体的水平相似。这些抗体在一周内有效地阻断了ACE 2受体与五种受关注变体的SARS-CoV-2刺突蛋白的结合，但在三个月后这种结合降低。87%的个体产生了刺突特异性记忆T细胞应答，这在免疫衰老CD 8 + TEMRA细胞比例增加的个体中较低。我们发现抗体反应与年龄呈负相关，与疫苗接种副作用总分呈正相关。mRNA疫苗在接种后1周诱导对SARS-CoV-2和5种VOC的强烈抗体应答，此后降低。T细胞反应，虽然在大多数可检测到的，在具有较高的T细胞免疫衰老的个体中较低。疫苗反应的恶化表明需要监测潜在的加强疫苗接种。
SARS-CoV-2 mRNA vaccines have proven high efficacy, however, limited data exists on the duration of immune responses and their relation to age and side effects. We studied the antibody and memory T cell responses after the two-dose BNT162b2 vaccine in 122 volunteers up to 6 months and correlated the findings with age and side effects. We found a robust antibody response to Spike protein after the second dose. However, the antibody levels declined at 12 weeks and 6 months post-vaccination, indicating a waning of the immune response over time. At 6 months after the second dose, the Spike antibody levels were similar to the levels in persons vaccinated with one dose or in COVID-19 convalescent individuals. The antibodies efficiently blocked ACE2 receptor binding to SARS-CoV-2 Spike protein of five variants of concern at one week but this was decreased at three months. 87% of individuals developed Spike-specific memory T cell responses, which were lower in individuals with increased proportions of immunosenescent CD8+ TEMRA cells. We found antibody response to correlate negatively with age and positively with the total score of vaccination side effects. The mRNA vaccine induces a strong antibody response to SARS-CoV-2 and five VOCs at 1 week post-vaccination that decreases thereafter. T cell responses, although detectable in the majority, were lower in individuals with higher T cell immunosenescence. The deterioration of vaccine response suggests the need to monitor for the potential booster vaccination.
登录
查看更多内容
影响因子：
32.4
作者：
Quast I;Tarlinton D
通讯作者：
Tarlinton D
影响因子：
64.8
作者：
Collier DA;Ferreira IATM;Kotagiri P;Datir RP;Lim EY;Touizer E;Meng B;Abdullahi A;CITIID-NIHR BioResource COVID-19 Collaboration;Elmer A;Kingston N;Graves B;Le Gresley E;Caputo D;Bergamaschi L;Smith KGC;Bradley JR;Ceron-Gutierrez L;Cortes-Acevedo P;Barcenas-Morales G;Linterman MA;McCoy LE;Davis C;Thomson E;Lyons PA;McKinney E;Doffinger R;Wills M;Gupta RK
通讯作者：
Gupta RK
影响因子：
64.8
作者：
Mulligan, Mark J.;Lyke, Kirsten E.;Jansen, Kathrin U.
通讯作者：
Jansen, Kathrin U.
DOI：
10.1016/s2666-5247(21)00025-2
发表时间：
2021-06
期刊：
The Lancet. Microbe
影响因子：
--
作者：
Chia WN;Zhu F;Ong SWX;Young BE;Fong SW;Le Bert N;Tan CW;Tiu C;Zhang J;Tan SY;Pada S;Chan YH;Tham CYL;Kunasegaran K;Chen MI;Low JGH;Leo YS;Renia L;Bertoletti A;Ng LFP;Lye DC;Wang LF
通讯作者：
Wang LF
影响因子：
64.8
作者：
Turner JS;O'Halloran JA;Kalaidina E;Kim W;Schmitz AJ;Zhou JQ;Lei T;Thapa M;Chen RE;Case JB;Amanat F;Rauseo AM;Haile A;Xie X;Klebert MK;Suessen T;Middleton WD;Shi PY;Krammer F;Teefey SA;Diamond MS;Presti RM;Ellebedy AH
通讯作者：
Ellebedy AH