Diversifying selective pressure on influenza B virus hemagglutinin.
Diversifying selective pressure on influenza B virus hemagglutinin.
复制标题
对流感B病毒血凝素的选择性压力多样化。
DOI：
10.1002/jmv.21335
复制
发表时间：
2009-01
影响因子：
12.7
通讯作者：
Wang, Qinghua
中科院分区：
文献类型：
--
作者：
Shen, Jun;Kirk, Brian D.;Ma, Jianpeng;Wang, Qinghua
乙型流感病毒血凝素（HA）是一种主要的表面糖蛋白，经常发生氨基酸替换。然而，抗体选择在HA的氨基酸取代中的作用仍然知之甚少。为了深入了解这一重要问题，对271个HA1进行了分析。1940-2007年间分离的乙型流感病毒株序列。在本分析中，系统发育分析采用最大似然（PAML）包来检测正选择的存在，并确定HA1上的正选择位点。值得注意的是，所有阳性选择位点都位于先前研究中发现的HA的四个主要表位（120环、150环、160环和190螺旋）上，从而支持抗体选择在HA进化中起主导作用。特别重要的是120环参与正选择，这可能在未来的野外分离中变得越来越重要。尽管没有不同的亚型，但乙型流感病毒HA继续进化成新的亚系，其中四个主要的表位在阳性选择中被选择性地靶向。因此，需要将任何新出现的毒株置于其进化历史的背景下，以便了解和预测其流行潜力。
Influenza B virus hemagglutinin (HA) is a major surface glycoprotein with frequent amino acid substitutions. However, the roles of antibody selection in the amino acid substitutions of HA were still poorly understood. In order to gain insights into this important issue, an analysis was conducted on a total of 271 HA1. sequences of influenza B virus strains isolated during 1940–2007. In this analysis, phylogenetic analysis by maximum likelihood (PAML) package was used to detect the existence of positive selection and to identify positively selected sites on HA1. Strikingly, all the positively selected sites were located in the four major epitopes (120-loop, 150-loop, 160-loop, and 190-helix) of HA identified in previous studies, thus supporting a predominant role of antibody selection in HA evolution. Of particular significance is the involvement of the 120-loop in positive selection, which may become increasingly important in future field isolates. Despite the absence of different subtypes, influenza B virus HA continued to evolve into new sublineages, within which the four major epitopes were targeted selectively in positive selection. Thus, any newly emerging strains need to be placed in the context of their evolutionary history in order to understand and predict their epidemic potential.
登录
查看更多内容
影响因子：
3.8
作者：
DANIELS, RS;DOUGLAS, AR;WILEY, DC
通讯作者：
WILEY, DC
影响因子：
3.7
作者：
BERTON, MT;WEBSTER, RG
通讯作者：
WEBSTER, RG
影响因子：
3.7
作者：
HOVANEC, DL;AIR, GM
通讯作者：
AIR, GM
影响因子：
4.2
作者：
Ikonen, N;Pyhälä, R;Korpela, H
通讯作者：
Korpela, H
DOI：
10.1073/pnas.79.15.4800
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
KRYSTAL, M;ELLIOTT, RM;PALESE, P
通讯作者：
PALESE, P