Age-related changes in human skeletal muscle microstructure and architecture assessed by diffusion-tensor magnetic resonance imaging and their association with muscle strength.
Age-related changes in human skeletal muscle microstructure and architecture assessed by diffusion-tensor magnetic resonance imaging and their association with muscle strength.
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扩散张量磁共振成像（DT-MRI）提供了肌肉特征的客观测量，提供了对年龄相关变化的见解。我们使用DT-MRI来探测大型健康老龄化队列中的骨骼肌微观结构和结构，目的是表征年龄相关差异并将其与肌肉力量进行比较。我们招募了94名参与者（43名女性;中位年龄= 56岁，范围= 22-89岁），并测量了12块大腿肌肉的微观结构参数-各向异性分数（FA）和平均扩散率（MD），以及股直肌（RF）和股长二头肌（BFL）的结构参数-羽状角，束长度，纤维曲率和生理横截面积（PCSA）。还测量了膝关节伸展和屈曲扭矩，以与结构测量进行比较。FA和MD与年龄相关（β = 0.33，p = 0.001，R2 = 0.10; β =-0.36，p < 0.001，R2 = 0.12），FA与文献中I型纤维比例呈负相关（β =-0.70，p = 0.024，R2 = 0.43）。在RF中，Pennation角、纤维曲率、束长和PCSA与年龄相关（β分别为-0.22，0.26，-0.23和-0.31; p < 0.05），而在BFL中，只有曲率和束长与年龄相关（β分别为0.36和-0.40; p < 0.001）。在RF中，Pennation角和PCSA与强度相关（β分别= 0.29和0.46; p < 0.01）;在BFL中，仅PCSA与强度相关（β = 0.43; p < 0.001）。我们的研究结果显示骨骼肌结构的变化与年龄和肌间的差异，在微观结构。DT-MRI可能有助于阐明肌肉减少症早期阶段的肌肉变化，并监测旨在预防导致功能障碍的肌肉中与年龄相关的微观结构变化的干预措施。我们使用扩散张量（DT）-MRI来探测健康老龄化队列中的肌肉微观结构和结构。我们观察到肌肉显微结构的年龄相关性-各向异性分数和平均扩散率-和结构-羽状角，束长度，纤维曲率和生理横截面积-以及结构和强度之间的相关性。DT-MRI可能有助于阐明肌肉减少症的肌肉变化，并允许监测减轻功能障碍的干预措施。
Diffusion‐tensor magnetic resonance imaging (DT‐MRI) offers objective measures of muscle characteristics, providing insights into age‐related changes. We used DT‐MRI to probe skeletal muscle microstructure and architecture in a large healthy‐aging cohort, with the aim of characterizing age‐related differences and comparing these to muscle strength. We recruited 94 participants (43 female; median age = 56, range = 22–89 years) and measured microstructure parameters—fractional anisotropy (FA) and mean diffusivity (MD)—in 12 thigh muscles, and architecture parameters—pennation angle, fascicle length, fiber curvature, and physiological cross‐sectional area (PCSA)—in the rectus femoris (RF) and biceps femoris longus (BFL). Knee extension and flexion torques were also measured for comparison to architecture measures. FA and MD were associated with age (β = 0.33, p = 0.001, R 2 = 0.10; and β = −0.36, p < 0.001, R 2 = 0.12), and FA was negatively associated with Type I fiber proportions from the literature (β = −0.70, p = 0.024, and R 2 = 0.43). Pennation angle, fiber curvature, fascicle length, and PCSA were associated with age in the RF (β = −0.22, 0.26, −0.23, and −0.31, respectively; p < 0.05), while in the BFL only curvature and fascicle length were associated with age (β = 0.36, and −0.40, respectively; p < 0.001). In the RF, pennation angle and PCSA were associated with strength (β = 0.29, and 0.46, respectively; p < 0.01); in the BFL, only PCSA was associated with strength (β = 0.43; p < 0.001). Our results show skeletal muscle architectural changes with aging and intermuscular differences in the microstructure. DT‐MRI may prove useful for elucidating muscle changes in the early stages of sarcopenia and monitoring interventions aimed at preventing age‐associated microstructural changes in muscle that lead to functional impairment. We used diffusion‐tensor (DT)‐MRI to probe muscle microstructure and architecture in a healthy‐aging cohort. We observed age associations in muscle microstructure—fractional anisotropy and mean diffusivity—and architecture—pennation angle, fascicle length, fiber curvature, and physiological cross‐sectional area—and associations between architecture and strength. DT‐MRI may help elucidate muscle changes in sarcopenia and permit monitoring of interventions for mitigating functional impairment.
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影响因子：
2.9
作者：
Froeling, Martijn;Nederveen, Aart J.;Strijkers, Gustav J.
通讯作者：
Strijkers, Gustav J.
影响因子：
3.3
作者：
Bolsterlee, Bart;D'Souza, Arkiev;Herbert, Robert D.
通讯作者：
Herbert, Robert D.
影响因子：
2.1
作者：
Koulouris, G;Connell, D
通讯作者：
Connell, D
影响因子：
3.3
作者：
Damon, BM;Ding, ZH;Gore, JC
通讯作者：
Gore, JC
影响因子：
3.3
作者：
Lansdown, Drew A.;Ding, Zhaohua;Damon, Bruce M.
通讯作者：
Damon, Bruce M.