Altered white matter connectivity in children with congenital heart disease with single ventricle physiology.
Altered white matter connectivity in children with congenital heart disease with single ventricle physiology.
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具有单个心室生理学的先天性心脏病儿童的白质连通性改变。
DOI：
10.1038/s41598-023-28634-9
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发表时间：
2023-01-24
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
由于外科手术的革新，先天性心脏病（CHD）患儿的死亡率大幅下降。然而，有许多与冠心病相关的危险因素可以破坏神经发育。最近的研究发现，心理缺陷和大脑结构异常会持续到成年。本研究的目的是研究患有复杂紫绀型冠心病（单心室生理）的学龄前儿童（6-11岁），与一组心脏健康、典型发育对照组（TPC）相比，接受Fontan姑息治疗的儿童的白质连通性。此外，我们调查了每组中白质束连通性和综合神经心理电池测量之间的关联。我们的研究结果表明，冠心病患者表现出广泛的白质连通性下降，这种下降的程度与几个认知领域的表现有关。网络拓扑分析表明，TPC组的集线器分布更为广泛和双边。我们的结果与先前的研究一致，表明围产期缺血导致白质病变和成熟延迟。
Children born with congenital heart disease (CHD) have seen a dramatic decrease in mortality thanks to surgical innovations. However, there are numerous risk factors associated with CHD that can disrupt neurodevelopment. Recent studies have found that psychological deficits and structural brain abnormalities persist into adulthood. The goal of the current study was to investigate white matter connectivity in early school-age children (6–11 years), born with complex cyanotic CHD (single ventricle physiology), who have undergone Fontan palliation, compared to a group of heart-healthy, typically developing controls (TPC). Additionally, we investigated associations between white matter tract connectivity and measures on a comprehensive neuropsychological battery within each group. Our results suggest CHD patients exhibit widespread decreases in white matter connectivity, and the extent of these decreases is related to performance in several cognitive domains. Analysis of network topology showed that hub distribution was more extensive and bilateral in the TPC group. Our results are consistent with previous studies suggesting perinatal ischemia leads to white matter lesions and delayed maturation.
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影响因子：
4.8
作者：
Ehrler M;Schlosser L;Brugger P;Greutmann M;Oxenius A;Kottke R;O'Gorman Tuura R;Latal B
通讯作者：
Latal B
影响因子：
5.7
作者：
Easson, Kaitlyn;Rohlicek, Charles, V;Brossard-Racine, Marie
通讯作者：
Brossard-Racine, Marie
影响因子：
24
作者：
Feinstein, Jeffrey A.;Benson, D. Woodrow;Martin, Gerard R.
通讯作者：
Martin, Gerard R.
DOI：
10.1017/s135561771400109x
发表时间：
2015-01-01
影响因子：
2.6
作者：
Brewster, Ryan C.;King, Tricia Z.;Mahle, William T.
通讯作者：
Mahle, William T.
影响因子：
4.1
作者：
Chao, Brandon K.;Claessens, Nathalie H. P.;Miller, Steven P.
通讯作者：
Miller, Steven P.