Altered white matter microstructure is related to cognition in adults with congenital heart disease.
Altered white matter microstructure is related to cognition in adults with congenital heart disease.
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DOI：
10.1093/braincomms/fcaa224
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发表时间：
2021
影响因子：
4.8
通讯作者：
Latal B
中科院分区：
文献类型：
--
作者：
Ehrler M;Schlosser L;Brugger P;Greutmann M;Oxenius A;Kottke R;O'Gorman Tuura R;Latal B
患有先天性心脏病的成年人有持续执行功能缺陷的风险，已知这会影响学业成绩和生活质量。白色微结构的改变与青少年先天性心脏病患者的认知障碍有关。本研究旨在确定与先天性心脏病成人执行功能缺陷潜在相关的微结构改变。对45名患者（18名女性）和54名健康对照（26名女性）进行了扩散张量成像和基于束的空间统计，年龄在18-32岁之间。比较各组之间白色物质扩散的各向异性分数，并与执行功能评分相关，该评分来自广泛的神经心理学测试组合。与对照组相比，患者双侧各向异性分数普遍降低（P < 0.05，多重比较校正）。具有中度和重度缺损复杂性的患者驱动较低的各向异性分数（与对照组相比：P < 0.001）。患者的执行功能评分较低（P < 0.05），并且与左侧上级放射冠和皮质脊髓束的各向异性分数较低相关（校正P < 0.05）。我们的研究结果证实了成人先天性心脏病患者白色物质微结构的改变，主要发生在中度至重度复杂性的患者中。这些改变与执行功能的障碍有关。更好地了解神经认知缺陷可能有助于咨询和照顾先天性心脏病患者的整个生命周期，并有可能改善他们的结果和生活质量。随着越来越多的先天性心脏病患者活到成年，人们对先天性心脏病与整个生命周期的神经发育之间的联系越来越感兴趣。这是第一项在成人先天性心脏病患者中进行的研究，证明了白色物质微结构的广泛改变以及与执行功能缺陷的相关性。
Adults with congenital heart disease are at risk for persisting executive function deficits, which are known to affect academic achievement and quality of life. Alterations in white -matter microstructure are associated with cognitive impairments in adolescents with congenital heart disease. This study aimed to identify microstructural alterations potentially associated with executive function deficits in adults with congenital heart disease. Diffusion tensor imaging and tract-based spatial statistics were conducted in 45 patients (18 females) and 54 healthy controls (26 females) aged 18–32 years. Fractional anisotropy of white matter diffusion was compared between groups and correlated with an executive function score, derived from an extensive neuropsychological test battery. Patients showed widespread bilateral reduction in fractional anisotropy (P < 0.05, multiple comparison corrected) compared to controls. Lower fractional anisotropy was driven by patients with moderate and severe defect complexity (compared to controls: P < 0.001). Executive function scores were lower in patients (P < 0.05) and associated with lower fractional anisotropy in the left superior corona radiata and the corticospinal tract (corrected P < 0.05). Our findings confirm alterations of white matter microstructure in adults with congenital heart disease, mainly in those patients of moderate to severe complexity. These alterations are associated with impairments in executive functioning. A better understanding of the neurocognitive deficits may help counselling and care of patients with congenital heart disease across their lifespan and have the potential to improve their outcome and quality of life. As more patients with congenital heart disease are surviving into adulthood, interest mounts in the link between congenital heart disease and neurodevelopment across the lifespan. This is the first study in adults with congenital heart disease, demonstrating widespread alterations in white matter microstructure and an association with executive function deficits.
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影响因子：
6.3
作者：
Gothe NP;Fanning J;Awick E;Chung D;Wójcicki TR;Olson EA;Mullen SP;Voss M;Erickson KI;Kramer AF;McAuley E
通讯作者：
McAuley E
DOI：
10.1017/s1355617714001027
发表时间：
2015-01
期刊：
Journal of the International Neuropsychological Society : JINS
影响因子：
--
作者：
Cassidy AR;White MT;DeMaso DR;Newburger JW;Bellinger DC
通讯作者：
Bellinger DC
影响因子：
5.7
作者：
Easson, Kaitlyn;Rohlicek, Charles, V;Brossard-Racine, Marie
通讯作者：
Brossard-Racine, Marie
DOI：
10.1017/s135561771400109x
发表时间：
2015-01-01
影响因子：
2.6
作者：
Brewster, Ryan C.;King, Tricia Z.;Mahle, William T.
通讯作者：
Mahle, William T.
影响因子：
5.3
作者：
Birca, Ala;Vakorin, Vasily A.;Porayette, Prashob;Madathil, Sujana;Chau, Vann;Seed, Mike;Doesburg, Sam M.;Blaser, Susan;Nita, Dragos A.;Sharma, Rohit;Duerden, Emma G.;Hickey, Edward J.;Miller, Steven P.;Hahn, Cecil D.
通讯作者：
Hahn, Cecil D.