Polypropylene modified with 2-hydroxyethyl acrylate-g-2-methacryloyloxyethyl phosphorycholine and its hemocompatibility
Polypropylene modified with 2-hydroxyethyl acrylate-g-2-methacryloyloxyethyl phosphorycholine and its hemocompatibility
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丙烯酸2-羟乙酯-g-2-甲基丙烯酰氧基乙基磷酸胆碱改性聚丙烯及其血液相容性
DOI：
10.1016/j.apsusc.2010.05.028
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发表时间：
2010-09
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
--
作者：
以丙烯酸羟乙酯(HEA)为接枝单体，采用溶液接枝的方法在PP主链上引入活性羟基(PP-g-HEA)对PP进行接枝。然后以硝酸高铈铵为引发剂，通过氧化还原接枝聚合将仿生单体2-甲基丙烯酰氧乙基磷胆碱(MPC)接枝到PP-g-HEA膜(PP-g-HEA-g-MPC)表面。傅立叶变换红外光谱(FTIR)和X射线光电子能谱(XPS)分析表明，HEA和MPC被引入到PP分子链上，形成了PP-g-HEA-g-MPC共聚物。水接触角测量表明，最终改性后的PP膜具有比纯PP膜更好的亲水性。用扫描电子显微镜观察了纯PP、PP-g-HEA和PP-g-HEA-g-MPC膜上的血小板黏附情况。结果表明，在平整的PP和PP-g-HEA薄膜表面有大量的血小板被黏附和激活，而PP-g-HEA-g-MPC表面的血小板数量明显减少。结果表明，PP表面引入了聚(MPC)，大大改善了PP的血液相容性。
Polypropylene (PP) was modified with 2-hydroxyethyl acrylate (HEA) by solution radical grafting to introduce active hydroxyl groups on polypropylene backbone (PP-g-HEA). Then the biomimic monomer, 2-methacryloyloxyethyl phosphorycholine (MPC), was grafted onto the surface of PP-g-HEA film (PP-g-HEA-g-MPC) by redox graft polymerizations with ceric(IV) ammonium nitrate as an initiator. Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) showed that the HEA and MPC were introduced onto PP molecular chains and the copolymer, PP-g-HEA-g-MPC were formed. The water contact angle measurements demonstrated that the final modified PP film exhibited a better hydrophilic surface compared to the neat PP film. The platelets adhesion on the neat PP, PP-g-HEA and PP-g-HEA-g-MPC film was examined by scanning electron microscopy (SEM). It was found that a large number of platelets were adhered and activated on the surface of neat PP and PP-g-HEA films, while the number of platelets on PP-g-HEA-g-MPC surface was decreased remarkably. The result revealed that the introduction of poly(MPC) onto the PP surface improved the hemocompatibility of PP substantially.
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影响因子：
5.4
作者：
Jin Wang;C. Pan;N. Huang;H. Sun;P. Yang;Y. Leng;J. Chen;G. Wan;P. Chu
通讯作者：
Jin Wang;C. Pan;N. Huang;H. Sun;P. Yang;Y. Leng;J. Chen;G. Wan;P. Chu
DOI：
10.1002/pola.22860
发表时间：
2008-08
期刊：
Journal of Polymer Science Part A
影响因子：
--
作者：
M. Değirmenci;Edip Taşkesen;Sirin Hicri;H. Yilmaz
通讯作者：
M. Değirmenci;Edip Taşkesen;Sirin Hicri;H. Yilmaz
影响因子：
14
作者：
Hasegawa, T;Iwasaki, Y;Ishihara, K
通讯作者：
Ishihara, K
影响因子：
3.9
作者：
K. Sugiyama;Takako Matsumoto;Yuki Yamazaki
通讯作者：
K. Sugiyama;Takako Matsumoto;Yuki Yamazaki
影响因子：
3
作者：
J. L. Han;Y. Chern;K. Hsieh;W. Chiu;C. Ma
通讯作者：
J. L. Han;Y. Chern;K. Hsieh;W. Chiu;C. Ma