Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility.
Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility.
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DOI：
10.3390/cells9102253
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发表时间：
2020-10-08
期刊：
影响因子：
6
通讯作者：
Al-Hendy A
中科院分区：
文献类型：
--
作者：
Esfandyari S;Chugh RM;Park HS;Hobeika E;Ulin M;Al-Hendy A
女性不孕症是一种全球性的医学疾病，可由生殖系统的各种疾病引起，包括卵巢早衰(POF)、多囊卵巢综合征(PCOS)、子宫内膜异位症、Asherman综合征和先兆子痫。它影响患者和夫妇的生活质量。间充质干细胞(MSCs)作为一种潜在的基于细胞的治疗方法受到越来越多的关注，与其他细胞来源相比具有许多优点，包括更多的细胞来源，更少的伦理考虑，以及高度的自我更新和分化能力。临床研究人员研究了骨髓间充质干细胞在女性不孕症中的治疗作用。在这篇综述中，我们讨论了最近关于骨髓间充质干细胞在导致不孕不育的各种生殖疾病中的应用研究。我们还描述了microRNAs(MiRNAs)和外体miRNAs在控制MSC基因表达和推动MSC治疗结果中的作用。骨髓间充质干细胞的临床应用为治疗不孕不育或卵巢功能不全以及改善全球相当数量的女性的生殖健康带来了巨大的希望。
Female infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. It affects the quality of life of both patients and couples. Mesenchymal stem cells (MSCs) have received increasing attention as a potential cell-based therapy, with several advantages over other cell sources, including greater abundance, fewer ethical considerations, and high capacity for self-renewal and differentiation. Clinical researchers have examined the therapeutic use of MSCs in female infertility. In this review, we discuss recent studies on the use of MSCs in various reproductive disorders that lead to infertility. We also describe the role of microRNAs (miRNAs) and exosomal miRNAs in controlling MSC gene expression and driving MSC therapeutic outcomes. The clinical application of MSCs holds great promise for the treatment of infertility or ovarian insufficiency, and to improve reproductive health for a significant number of women worldwide.
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影响因子：
7.4
作者：
Choudhery MS;Badowski M;Muise A;Pierce J;Harris DT
通讯作者：
Harris DT
DOI：
10.1186/s12958-015-0104-2
发表时间：
2015-09-23
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Damous LL;Nakamuta JS;Carvalho AE;Carvalho KC;Soares JM Jr;Simões Mde J;Krieger JE;Baracat EC
通讯作者：
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影响因子：
3.7
作者：
Altaner C;Altanerova V;Cihova M;Hunakova L;Kaiserova K;Klepanec A;Vulev I;Madaric J
通讯作者：
Madaric J
影响因子：
3.7
作者：
Alawadhi F;Du H;Cakmak H;Taylor HS
通讯作者：
Taylor HS
影响因子：
9.1
作者：
Ding, Lijun;Yan, Guijun;Sun, Haixiang
通讯作者：
Sun, Haixiang